Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery

Birha McCann, Christine Miaskowski, Theresa Koetters, Christina Baggott, Claudia West, Jon D. Levine, Charles Elboim, Gary Abrams, Deborah Hamolsky, Laura Dunn, Hope Rugo, Marylin Dodd, Steven M. Paul, John Neuhaus, Bruce Cooper, Brian Schmidt, Dale Langford, Janine Cataldo, Bradley E. Aouizerat

Research output: Contribution to journalArticle

Abstract

The purposes of this study were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n = 398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (P <.001); more likely to be nonwhite (P =.032); reported significantly lower Karnofsky Performance Status scores (P =.008); were less likely to be postmenopausal (P =.012); and had undergone significantly more biopsies (P =.006). Carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (P =.007). Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P =.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain. Perspective: In women with breast cancer, preoperative pain may be associated with increases in inflammatory responses associated with an increased number of biopsies. In addition, differences in cytokine genes may contribute to this preoperative breast pain.

Original languageEnglish (US)
Pages (from-to)425-437
Number of pages13
JournalJournal of Pain
Volume13
Issue number5
DOIs
StatePublished - May 2012

Fingerprint

Mastodynia
Anti-Inflammatory Agents
Breast Neoplasms
Cytokines
Genes
Pain
Single Nucleotide Polymorphism
Alleles
Biopsy
Karnofsky Performance Status
Interleukin-1 Receptors
Interleukin-13
Self Report
Demography

Keywords

  • Breast pain
  • cytokine genes
  • inflammation
  • preoperative pain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology

Cite this

Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery. / McCann, Birha; Miaskowski, Christine; Koetters, Theresa; Baggott, Christina; West, Claudia; Levine, Jon D.; Elboim, Charles; Abrams, Gary; Hamolsky, Deborah; Dunn, Laura; Rugo, Hope; Dodd, Marylin; Paul, Steven M.; Neuhaus, John; Cooper, Bruce; Schmidt, Brian; Langford, Dale; Cataldo, Janine; Aouizerat, Bradley E.

In: Journal of Pain, Vol. 13, No. 5, 05.2012, p. 425-437.

Research output: Contribution to journalArticle

McCann, B, Miaskowski, C, Koetters, T, Baggott, C, West, C, Levine, JD, Elboim, C, Abrams, G, Hamolsky, D, Dunn, L, Rugo, H, Dodd, M, Paul, SM, Neuhaus, J, Cooper, B, Schmidt, B, Langford, D, Cataldo, J & Aouizerat, BE 2012, 'Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery', Journal of Pain, vol. 13, no. 5, pp. 425-437. https://doi.org/10.1016/j.jpain.2011.02.358
McCann, Birha ; Miaskowski, Christine ; Koetters, Theresa ; Baggott, Christina ; West, Claudia ; Levine, Jon D. ; Elboim, Charles ; Abrams, Gary ; Hamolsky, Deborah ; Dunn, Laura ; Rugo, Hope ; Dodd, Marylin ; Paul, Steven M. ; Neuhaus, John ; Cooper, Bruce ; Schmidt, Brian ; Langford, Dale ; Cataldo, Janine ; Aouizerat, Bradley E. / Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery. In: Journal of Pain. 2012 ; Vol. 13, No. 5. pp. 425-437.
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AU - West, Claudia

AU - Levine, Jon D.

AU - Elboim, Charles

AU - Abrams, Gary

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AU - Rugo, Hope

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AU - Paul, Steven M.

AU - Neuhaus, John

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N2 - The purposes of this study were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n = 398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (P <.001); more likely to be nonwhite (P =.032); reported significantly lower Karnofsky Performance Status scores (P =.008); were less likely to be postmenopausal (P =.012); and had undergone significantly more biopsies (P =.006). Carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (P =.007). Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P =.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain. Perspective: In women with breast cancer, preoperative pain may be associated with increases in inflammatory responses associated with an increased number of biopsies. In addition, differences in cytokine genes may contribute to this preoperative breast pain.

AB - The purposes of this study were to determine the occurrence rate for preoperative breast pain; describe the characteristics of this pain; evaluate for differences in demographic and clinical characteristics; and evaluate for variations in pro- and anti-inflammatory cytokine genes between women who did and did not report pain. Patients (n = 398) were recruited prior to surgery and completed self-report questionnaires on a number of pain characteristics. Genotyping was done using a custom genotyping array. Women (28.2%) who reported breast pain were significantly younger (P <.001); more likely to be nonwhite (P =.032); reported significantly lower Karnofsky Performance Status scores (P =.008); were less likely to be postmenopausal (P =.012); and had undergone significantly more biopsies (P =.006). Carriers of the minor allele for a single nucleotide polymorphism in interleukin (IL)1-receptor 1 (IL1R1) (rs2110726) were less likely to report breast pain prior to surgery (P =.007). Carriers of the minor allele for a single nucleotide polymorphism in IL13 (rs1295686) were more likely to report breast pain prior to surgery (P =.019). Findings suggest that breast pain occurs in over a quarter of women who are about to undergo breast cancer surgery. Based on phenotypic and genotypic characteristics found, inflammatory mechanisms contribute to preoperative breast pain. Perspective: In women with breast cancer, preoperative pain may be associated with increases in inflammatory responses associated with an increased number of biopsies. In addition, differences in cytokine genes may contribute to this preoperative breast pain.

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