Associations Between Neurocognitive Impairment and Biomarkers of Poor Physiologic Reserve in a Clinic-Based Sample of Older Adults Living with HIV

Kalvin C. Yu, Paul A. D'Avanzo, Leigh Nesheiwat, Richard E. Greene, Antonio Urbina, Perry N. Halkitis, Farzana Kapadia

Research output: Contribution to journalArticle

Abstract

Data from a cross-sectional study of a clinic-based sample of older people living with HIV (PLWH; n = 100) were used to examine associations between biomarkers of physical health and neurocognitive impairment (NCI). In this sample, anemia, chronic kidney disease (CKD) stages 4-5, and hypocalcemia were associated with impairment in executive functioning or processing speed. Furthermore, participants with anemia were more likely to have CD4+ T cell counts <200 cells/mm32 [1] = 19.57, p < .001); hypocalcemia (χ2 [1] = 17.55, p < .001); and CKD 4-5 (χ2 [2] = 10.12, p = .006). Black and Hispanic participants were more likely to be anemic compared to other races and ethnicities (χ2 [3] = 12.76, p = .005). Common medical conditions (e.g., anemia, hypocalcemia, CKD) should be investigated as potential contributors to NCI in older PLWH. Additionally, laboratory testing in racial/ethnic minority PLWH may help inform NCI screening.

Original languageEnglish (US)
JournalJournal of the Association of Nurses in AIDS Care
DOIs
StateAccepted/In press - 2016

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Hypocalcemia
Chronic Renal Insufficiency
Anemia
Biomarkers
HIV
CD4 Lymphocyte Count
Hispanic Americans
Cross-Sectional Studies
T-Lymphocytes
Health

Keywords

  • HIV
  • Neurocognitive impairment
  • Screening

ASJC Scopus subject areas

  • Advanced and Specialized Nursing

Cite this

Associations Between Neurocognitive Impairment and Biomarkers of Poor Physiologic Reserve in a Clinic-Based Sample of Older Adults Living with HIV. / Yu, Kalvin C.; D'Avanzo, Paul A.; Nesheiwat, Leigh; Greene, Richard E.; Urbina, Antonio; Halkitis, Perry N.; Kapadia, Farzana.

In: Journal of the Association of Nurses in AIDS Care, 2016.

Research output: Contribution to journalArticle

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