Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery

Sy Huey Doong, Anand Dhruva, Laura B. Dunn, Claudia West, Steven M. Paul, Bruce A. Cooper, Charles Elboim, Gary Abrams, John D. Merriman, Dale J. Langford, Heather Leutwyler, Christina Baggott, Kord Kober, Bradley E. Aouizerat, Christine Miaskowski

Research output: Contribution to journalArticle

Abstract

Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of proinflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (n = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: “all low” (61.0%), “low pain and high fatigue” (31.6%), “all high” (7.1%). Compared to patients in the all low class, patients in the all high class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin 6 (IL6) rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.

Original languageEnglish (US)
Pages (from-to)237-247
Number of pages11
JournalBiological Research for Nursing
Volume17
Issue number3
DOIs
StatePublished - May 4 2015

Fingerprint

Fatigue
Sleep
Depression
Breast Neoplasms
Cytokines
Pain
Genes
Interleukin-13
Comorbidity
Interleukin-6
Anti-Inflammatory Agents
Tumor Necrosis Factor-alpha
Demography
Education

Keywords

  • candidate genes
  • cytokines
  • depression
  • fatigue
  • interleukin
  • pain
  • sleep disturbance
  • symptom cluster
  • tumor necrosis factor alpha

ASJC Scopus subject areas

  • Research and Theory

Cite this

Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery. / Doong, Sy Huey; Dhruva, Anand; Dunn, Laura B.; West, Claudia; Paul, Steven M.; Cooper, Bruce A.; Elboim, Charles; Abrams, Gary; Merriman, John D.; Langford, Dale J.; Leutwyler, Heather; Baggott, Christina; Kober, Kord; Aouizerat, Bradley E.; Miaskowski, Christine.

In: Biological Research for Nursing, Vol. 17, No. 3, 04.05.2015, p. 237-247.

Research output: Contribution to journalArticle

Doong, SH, Dhruva, A, Dunn, LB, West, C, Paul, SM, Cooper, BA, Elboim, C, Abrams, G, Merriman, JD, Langford, DJ, Leutwyler, H, Baggott, C, Kober, K, Aouizerat, BE & Miaskowski, C 2015, 'Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery', Biological Research for Nursing, vol. 17, no. 3, pp. 237-247. https://doi.org/10.1177/1099800414550394
Doong, Sy Huey ; Dhruva, Anand ; Dunn, Laura B. ; West, Claudia ; Paul, Steven M. ; Cooper, Bruce A. ; Elboim, Charles ; Abrams, Gary ; Merriman, John D. ; Langford, Dale J. ; Leutwyler, Heather ; Baggott, Christina ; Kober, Kord ; Aouizerat, Bradley E. ; Miaskowski, Christine. / Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery. In: Biological Research for Nursing. 2015 ; Vol. 17, No. 3. pp. 237-247.
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