Associations among four modalities of experimental pain in women

Kanokporn Bhalang, Asgeir Sigurdsson, Gary D. Slade, William Maixner

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the associations among 4 measures of pain induction procedures in 244 healthy women. The procedures were (1) pressure pain threshold assessed over the temporalis muscles, masseter muscles, temporomandibular joints, and the wrists; (2) C fiber-mediated heat pain threshold/tolerance assessed on the skin over the forearm, cheek, and dorsal aspect of the foot; (3) temporal summation of C fiber-mediated heat pain; and (4) ischemic pain threshold/tolerance. Strong associations among pressure pain thresholds at the 4 sites examined (ρ = 0.7 to 0.8, P values ≤ .001) and among heat pain threshold/tolerance values at the 3 sites examined (ρ = 0.6 to 0.9, P values ≤ .001) were observed. Pressure pain threshold was moderately correlated with each of the heat pain threshold/tolerance values (ρ = 0.2 to 0.4, P values ≤ .001). Ischemic pain threshold/tolerance was moderately associated with each of the pressure and heat pain measures (ρ = 0.2 to 0.3, P values ≤ .05 to .001). Derived measures of the temporal summation of heat pain did not correlate strongly with threshold or tolerance measures of pressure, ischemic, or heat pain. We concluded (1) that for a specific pain modality, the correlation between threshold and tolerance values across anatomic sites is high, and (2) that measures of pressure, ischemic, and thermal pain threshold/tolerance are significantly correlated, although the strength of these associations is moderate. These findings demonstrate that a battery of pain-assessing procedures is required to determine an individual's pain sensitivity profile or phenotype.

Original languageEnglish (US)
Pages (from-to)604-611
Number of pages8
JournalJournal of Pain
Volume6
Issue number9
DOIs
StatePublished - Sep 2005

Fingerprint

Pain Threshold
Hot Temperature
Pain
Pressure
Unmyelinated Nerve Fibers
Masseter Muscle
Cheek
Temporomandibular Joint
Wrist
Forearm
Foot
Phenotype
Muscles
Skin

Keywords

  • Correlation
  • Human experimental pain
  • Ischemic pain
  • Pressure pain thresholds
  • Thermal pain
  • Windup

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Associations among four modalities of experimental pain in women. / Bhalang, Kanokporn; Sigurdsson, Asgeir; Slade, Gary D.; Maixner, William.

In: Journal of Pain, Vol. 6, No. 9, 09.2005, p. 604-611.

Research output: Contribution to journalArticle

Bhalang, Kanokporn ; Sigurdsson, Asgeir ; Slade, Gary D. ; Maixner, William. / Associations among four modalities of experimental pain in women. In: Journal of Pain. 2005 ; Vol. 6, No. 9. pp. 604-611.
@article{a87f454f3a4540938cebfcca2b4a36d0,
title = "Associations among four modalities of experimental pain in women",
abstract = "The aim of this study was to investigate the associations among 4 measures of pain induction procedures in 244 healthy women. The procedures were (1) pressure pain threshold assessed over the temporalis muscles, masseter muscles, temporomandibular joints, and the wrists; (2) C fiber-mediated heat pain threshold/tolerance assessed on the skin over the forearm, cheek, and dorsal aspect of the foot; (3) temporal summation of C fiber-mediated heat pain; and (4) ischemic pain threshold/tolerance. Strong associations among pressure pain thresholds at the 4 sites examined (ρ = 0.7 to 0.8, P values ≤ .001) and among heat pain threshold/tolerance values at the 3 sites examined (ρ = 0.6 to 0.9, P values ≤ .001) were observed. Pressure pain threshold was moderately correlated with each of the heat pain threshold/tolerance values (ρ = 0.2 to 0.4, P values ≤ .001). Ischemic pain threshold/tolerance was moderately associated with each of the pressure and heat pain measures (ρ = 0.2 to 0.3, P values ≤ .05 to .001). Derived measures of the temporal summation of heat pain did not correlate strongly with threshold or tolerance measures of pressure, ischemic, or heat pain. We concluded (1) that for a specific pain modality, the correlation between threshold and tolerance values across anatomic sites is high, and (2) that measures of pressure, ischemic, and thermal pain threshold/tolerance are significantly correlated, although the strength of these associations is moderate. These findings demonstrate that a battery of pain-assessing procedures is required to determine an individual's pain sensitivity profile or phenotype.",
keywords = "Correlation, Human experimental pain, Ischemic pain, Pressure pain thresholds, Thermal pain, Windup",
author = "Kanokporn Bhalang and Asgeir Sigurdsson and Slade, {Gary D.} and William Maixner",
year = "2005",
month = "9",
doi = "10.1016/j.jpain.2005.04.006",
language = "English (US)",
volume = "6",
pages = "604--611",
journal = "Journal of Pain",
issn = "1526-5900",
publisher = "Churchill Livingstone",
number = "9",

}

TY - JOUR

T1 - Associations among four modalities of experimental pain in women

AU - Bhalang, Kanokporn

AU - Sigurdsson, Asgeir

AU - Slade, Gary D.

AU - Maixner, William

PY - 2005/9

Y1 - 2005/9

N2 - The aim of this study was to investigate the associations among 4 measures of pain induction procedures in 244 healthy women. The procedures were (1) pressure pain threshold assessed over the temporalis muscles, masseter muscles, temporomandibular joints, and the wrists; (2) C fiber-mediated heat pain threshold/tolerance assessed on the skin over the forearm, cheek, and dorsal aspect of the foot; (3) temporal summation of C fiber-mediated heat pain; and (4) ischemic pain threshold/tolerance. Strong associations among pressure pain thresholds at the 4 sites examined (ρ = 0.7 to 0.8, P values ≤ .001) and among heat pain threshold/tolerance values at the 3 sites examined (ρ = 0.6 to 0.9, P values ≤ .001) were observed. Pressure pain threshold was moderately correlated with each of the heat pain threshold/tolerance values (ρ = 0.2 to 0.4, P values ≤ .001). Ischemic pain threshold/tolerance was moderately associated with each of the pressure and heat pain measures (ρ = 0.2 to 0.3, P values ≤ .05 to .001). Derived measures of the temporal summation of heat pain did not correlate strongly with threshold or tolerance measures of pressure, ischemic, or heat pain. We concluded (1) that for a specific pain modality, the correlation between threshold and tolerance values across anatomic sites is high, and (2) that measures of pressure, ischemic, and thermal pain threshold/tolerance are significantly correlated, although the strength of these associations is moderate. These findings demonstrate that a battery of pain-assessing procedures is required to determine an individual's pain sensitivity profile or phenotype.

AB - The aim of this study was to investigate the associations among 4 measures of pain induction procedures in 244 healthy women. The procedures were (1) pressure pain threshold assessed over the temporalis muscles, masseter muscles, temporomandibular joints, and the wrists; (2) C fiber-mediated heat pain threshold/tolerance assessed on the skin over the forearm, cheek, and dorsal aspect of the foot; (3) temporal summation of C fiber-mediated heat pain; and (4) ischemic pain threshold/tolerance. Strong associations among pressure pain thresholds at the 4 sites examined (ρ = 0.7 to 0.8, P values ≤ .001) and among heat pain threshold/tolerance values at the 3 sites examined (ρ = 0.6 to 0.9, P values ≤ .001) were observed. Pressure pain threshold was moderately correlated with each of the heat pain threshold/tolerance values (ρ = 0.2 to 0.4, P values ≤ .001). Ischemic pain threshold/tolerance was moderately associated with each of the pressure and heat pain measures (ρ = 0.2 to 0.3, P values ≤ .05 to .001). Derived measures of the temporal summation of heat pain did not correlate strongly with threshold or tolerance measures of pressure, ischemic, or heat pain. We concluded (1) that for a specific pain modality, the correlation between threshold and tolerance values across anatomic sites is high, and (2) that measures of pressure, ischemic, and thermal pain threshold/tolerance are significantly correlated, although the strength of these associations is moderate. These findings demonstrate that a battery of pain-assessing procedures is required to determine an individual's pain sensitivity profile or phenotype.

KW - Correlation

KW - Human experimental pain

KW - Ischemic pain

KW - Pressure pain thresholds

KW - Thermal pain

KW - Windup

UR - http://www.scopus.com/inward/record.url?scp=32944472768&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32944472768&partnerID=8YFLogxK

U2 - 10.1016/j.jpain.2005.04.006

DO - 10.1016/j.jpain.2005.04.006

M3 - Article

VL - 6

SP - 604

EP - 611

JO - Journal of Pain

JF - Journal of Pain

SN - 1526-5900

IS - 9

ER -