Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin D levels

National Health and Nutrition Examination Survey (2001-2006)

Stephen K. Williams, Kevin Fiscella, Paul Winters, David Martins, Gbenga Ogedegbe

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that racial differences in vitamin D levels are associated with racial disparities in insulin resistance between blacks and whites. Among 3628 non-Hispanic black and white adults in the National Health and Nutrition Examination Survey from 2001 to 2006, we examined the association between race and insulin resistance using the homeostasis assessment model for insulin resistance. We conducted analyses with and without serum 25-hydroxyvitamin D (25[OH]D). We adjusted for age, sex, educational level, body mass index, waist circumference, physical activity, alcohol intake, smoking, estimated glomerular filtration rate, and urinary albumin/creatinine ratio. Blacks had a lower mean serum 25(OH)D level compared with whites (14.6 [0.3] ng/mL vs 25.6 [0.4] ng/mL, respectively; P <.0001). Blacks had a higher odds ratio (OR) for insulin resistance without controlling for serum 25(OH)D levels (OR, 1.67; 95% confidence interval, 1.26-2.20). The association was not significant (OR, 1.28; 95% confidence interval, 0.90-1.82) after accounting for serum 25(OH)D levels. The higher burden of insulin resistance in blacks compared with whites may be partially mediated by the disparity in serum 25(OH)D levels.

Original languageEnglish (US)
Pages (from-to)266-271
Number of pages6
JournalNutrition Research
Volume33
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Nutrition Surveys
Vitamin D
Health Status
Insulin Resistance
Serum
Odds Ratio
Confidence Intervals
Waist Circumference
Glomerular Filtration Rate
Albumins
Creatinine
Body Mass Index
Homeostasis
Smoking
Alcohols
Exercise
hydroquinone

Keywords

  • African Americans
  • Cohort studies
  • Insulin resistance
  • Minority health
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Association of racial disparities in the prevalence of insulin resistance with racial disparities in vitamin D levels : National Health and Nutrition Examination Survey (2001-2006). / Williams, Stephen K.; Fiscella, Kevin; Winters, Paul; Martins, David; Ogedegbe, Gbenga.

In: Nutrition Research, Vol. 33, No. 4, 04.2013, p. 266-271.

Research output: Contribution to journalArticle

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