Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study

Chengchen Li, Zeyuan Wang, Theresa Hardy, Yunfeng Huang, Qin Hui, Cindy A. Crusto, Michelle L. Wright, Jacquelyn Taylor, Yan V. Sun

Research output: Contribution to journalArticle

Abstract

African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjusting for smoking, hypertension diagnosis history, and socioeconomic factors (education, marital status, household income), a 1 kg/m2 increase in BMI is associated with 0.14 years increment of DNAm AA (95% CI: (0.08, 0.21)). The conclusion: in African American women, high BMI is independently associated with saliva-based DNA methylation age acceleration, after adjusting for smoking, hypertension, and socioeconomic status. This finding supports that high BMI accelerates biological aging, and plays a key role in age-related disease outcomes among African American women.

Original languageEnglish (US)
JournalInternational journal of molecular sciences
Volume20
Issue number17
DOIs
StatePublished - Aug 31 2019

Fingerprint

obesity
methylation
DNA Methylation
African Americans
deoxyribonucleic acid
Obesity
Mothers
Body Mass Index
Aging of materials
saliva
hypertension
Saliva
Smoking
adjusting
Hypertension
income
Biological Phenomena
biomarkers
Marital Status
Biomarkers

Keywords

  • African American
  • aging
  • BMI
  • DNA methylation age acceleration
  • obesity

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study. / Li, Chengchen; Wang, Zeyuan; Hardy, Theresa; Huang, Yunfeng; Hui, Qin; Crusto, Cindy A.; Wright, Michelle L.; Taylor, Jacquelyn; Sun, Yan V.

In: International journal of molecular sciences, Vol. 20, No. 17, 31.08.2019.

Research output: Contribution to journalArticle

Li, Chengchen ; Wang, Zeyuan ; Hardy, Theresa ; Huang, Yunfeng ; Hui, Qin ; Crusto, Cindy A. ; Wright, Michelle L. ; Taylor, Jacquelyn ; Sun, Yan V. / Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study. In: International journal of molecular sciences. 2019 ; Vol. 20, No. 17.
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