Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs

Ene Ly Jõgeda, Radko Avi, Merit Pauskar, Eveli Kallas, Tõnis Karki, Don Des Jarlais, Anneli Uusküla, Karolin Toompere, Irja Lutsar, Kristi Huik

Research output: Contribution to journalArticle

Abstract

We investigated the presence of a single-nucleotide polymorphism designated rs12979860 in the interferon λ4 (IFNλ4) gene among 345 people who inject drugs (PWID) and 495 blood donors to evaluate associations between the rs12979860 genotypes and human immunodeficiency virus/hepatitis C virus (HIV/HCV). The rs12979860 TT genotype was over-represented among HIV+ PWID than HIV− PWID and blood donors (16% vs 8% and 10%, P = 0.03, respectively). PWID with TT genotype had approximately twice the probability of being HIV+ (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.11 to 4.33) than PWID without TT. Every additional year of intravenous drug use (IVDU) decreased the OR 1.16 times (OR, 0.86; 95% CI, 0.75 to 0.98). This suggests that rs12979860 TT increases susceptibility to HIV and this impact decreases with increasing duration of IVDU.

Original languageEnglish (US)
Pages (from-to)1779-1783
Number of pages5
JournalJournal of Medical Virology
Volume90
Issue number11
DOIs
StatePublished - Nov 1 2018

Fingerprint

Interferons
HIV Infections
HIV
Pharmaceutical Preparations
Odds Ratio
Genotype
Blood Donors
Confidence Intervals
Hepatitis
Single Nucleotide Polymorphism
Genes

Keywords

  • Hepatitis C Virus
  • human immune deficiency virus/hepatitis C virus coinfection
  • Human Immunodeficiency Virus
  • interferon λ
  • Interferons
  • interleukin-28B
  • IVDU

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. / Jõgeda, Ene Ly; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Toompere, Karolin; Lutsar, Irja; Huik, Kristi.

In: Journal of Medical Virology, Vol. 90, No. 11, 01.11.2018, p. 1779-1783.

Research output: Contribution to journalArticle

Jõgeda, EL, Avi, R, Pauskar, M, Kallas, E, Karki, T, Des Jarlais, D, Uusküla, A, Toompere, K, Lutsar, I & Huik, K 2018, 'Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs', Journal of Medical Virology, vol. 90, no. 11, pp. 1779-1783. https://doi.org/10.1002/jmv.25258
Jõgeda, Ene Ly ; Avi, Radko ; Pauskar, Merit ; Kallas, Eveli ; Karki, Tõnis ; Des Jarlais, Don ; Uusküla, Anneli ; Toompere, Karolin ; Lutsar, Irja ; Huik, Kristi. / Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. In: Journal of Medical Virology. 2018 ; Vol. 90, No. 11. pp. 1779-1783.
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