Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in hispanic postmenopausal women

Gerald B. Phillips, Catherine H. Tuck, Tian Yi Jing, Bernadette Boden-Albala, I. Feng Lin, Nabila Dahodwala, Ralph L. Sacco

Research output: Contribution to journalArticle

Abstract

OBJECTIVE - Accumulating evidence suggests that hyperandrogenemia may be a risk factor for coronary heart disease (CHD) in women. The present study was carried out to test the hypothesis that hyperandrogenemia is associated with type 2 diabetes in women and thus may contribute to the increased risk of CHD in women with type 2 diabetes. RESEARCH DESIGN AND METHODS - Sex hormones, sex hormone-binding globulin (SHBG), and risk factors for CHD were measured in 20 postmenopausal women with type 2 diabetes and in 29 control subjects. All of the diabetic and control subjects were Hispanic women aged >55 years who were not taking hormone replacement therapy, lipid-lowering drugs, or insulin and who were otherwise randomly chosen from a cohort of stroke-free subjects from the Northern Manhattan Stroke Study. RESULTS - Mean age, BMI, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, and smoking were not significantly different between cases and control subjects, but waist-to-hip ratio (WHR) was significantly higher in the diabetic subjects (P = 0.01). The mean levels of free testosterone (FT) (P = 0.01), dehydroepiandrosterone sulfate (P < 0.04), and estradiol (P = 0.01) (controlled for WHR) were significantly higher in the diabetic subjects; with the statistical outliers removed, the testosterone (P = 0.05) and androstenedione (P = 0.002) levels (controlled for WHR) were also significantly higher in the diabetic subjects. The mean levels of estrone, cortisol, and SHBG were not significantly different. The results were similar in the 10 diabetic subjects treated with diet only. Significant positive correlations (controlled for age and BMI) were observed between FT or testosterone and cholesterol, LDL cholesterol, and blood pressure. CONCLUSIONS - Postmenopausal Hispanic women with type 2 diabetes had both hyperandrogenemia and hyperestrogenemia, and testosterone or FT correlated positively with risk factors for CHD. Hyperandrogenemia may be a link between diabetes and CHD in women.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalDiabetes Care
Volume23
Issue number1
StatePublished - 2000

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Hispanic Americans
Type 2 Diabetes Mellitus
Testosterone
Coronary Disease
Waist-Hip Ratio
Sex Hormone-Binding Globulin
LDL Cholesterol
Stroke
Cholesterol
Blood Pressure
Dehydroepiandrosterone Sulfate
Androstenedione
Estrone
Hormone Replacement Therapy
Gonadal Steroid Hormones
HDL Cholesterol
Hydrocortisone
Estradiol
Triglycerides
Research Design

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Phillips, G. B., Tuck, C. H., Jing, T. Y., Boden-Albala, B., Lin, I. F., Dahodwala, N., & Sacco, R. L. (2000). Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in hispanic postmenopausal women. Diabetes Care, 23(1), 74-79.

Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in hispanic postmenopausal women. / Phillips, Gerald B.; Tuck, Catherine H.; Jing, Tian Yi; Boden-Albala, Bernadette; Lin, I. Feng; Dahodwala, Nabila; Sacco, Ralph L.

In: Diabetes Care, Vol. 23, No. 1, 2000, p. 74-79.

Research output: Contribution to journalArticle

Phillips, GB, Tuck, CH, Jing, TY, Boden-Albala, B, Lin, IF, Dahodwala, N & Sacco, RL 2000, 'Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in hispanic postmenopausal women', Diabetes Care, vol. 23, no. 1, pp. 74-79.
Phillips, Gerald B. ; Tuck, Catherine H. ; Jing, Tian Yi ; Boden-Albala, Bernadette ; Lin, I. Feng ; Dahodwala, Nabila ; Sacco, Ralph L. / Association of hyperandrogenemia and hyperestrogenemia with type 2 diabetes in hispanic postmenopausal women. In: Diabetes Care. 2000 ; Vol. 23, No. 1. pp. 74-79.
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abstract = "OBJECTIVE - Accumulating evidence suggests that hyperandrogenemia may be a risk factor for coronary heart disease (CHD) in women. The present study was carried out to test the hypothesis that hyperandrogenemia is associated with type 2 diabetes in women and thus may contribute to the increased risk of CHD in women with type 2 diabetes. RESEARCH DESIGN AND METHODS - Sex hormones, sex hormone-binding globulin (SHBG), and risk factors for CHD were measured in 20 postmenopausal women with type 2 diabetes and in 29 control subjects. All of the diabetic and control subjects were Hispanic women aged >55 years who were not taking hormone replacement therapy, lipid-lowering drugs, or insulin and who were otherwise randomly chosen from a cohort of stroke-free subjects from the Northern Manhattan Stroke Study. RESULTS - Mean age, BMI, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, and smoking were not significantly different between cases and control subjects, but waist-to-hip ratio (WHR) was significantly higher in the diabetic subjects (P = 0.01). The mean levels of free testosterone (FT) (P = 0.01), dehydroepiandrosterone sulfate (P < 0.04), and estradiol (P = 0.01) (controlled for WHR) were significantly higher in the diabetic subjects; with the statistical outliers removed, the testosterone (P = 0.05) and androstenedione (P = 0.002) levels (controlled for WHR) were also significantly higher in the diabetic subjects. The mean levels of estrone, cortisol, and SHBG were not significantly different. The results were similar in the 10 diabetic subjects treated with diet only. Significant positive correlations (controlled for age and BMI) were observed between FT or testosterone and cholesterol, LDL cholesterol, and blood pressure. CONCLUSIONS - Postmenopausal Hispanic women with type 2 diabetes had both hyperandrogenemia and hyperestrogenemia, and testosterone or FT correlated positively with risk factors for CHD. Hyperandrogenemia may be a link between diabetes and CHD in women.",
author = "Phillips, {Gerald B.} and Tuck, {Catherine H.} and Jing, {Tian Yi} and Bernadette Boden-Albala and Lin, {I. Feng} and Nabila Dahodwala and Sacco, {Ralph L.}",
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AU - Phillips, Gerald B.

AU - Tuck, Catherine H.

AU - Jing, Tian Yi

AU - Boden-Albala, Bernadette

AU - Lin, I. Feng

AU - Dahodwala, Nabila

AU - Sacco, Ralph L.

PY - 2000

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AB - OBJECTIVE - Accumulating evidence suggests that hyperandrogenemia may be a risk factor for coronary heart disease (CHD) in women. The present study was carried out to test the hypothesis that hyperandrogenemia is associated with type 2 diabetes in women and thus may contribute to the increased risk of CHD in women with type 2 diabetes. RESEARCH DESIGN AND METHODS - Sex hormones, sex hormone-binding globulin (SHBG), and risk factors for CHD were measured in 20 postmenopausal women with type 2 diabetes and in 29 control subjects. All of the diabetic and control subjects were Hispanic women aged >55 years who were not taking hormone replacement therapy, lipid-lowering drugs, or insulin and who were otherwise randomly chosen from a cohort of stroke-free subjects from the Northern Manhattan Stroke Study. RESULTS - Mean age, BMI, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, and smoking were not significantly different between cases and control subjects, but waist-to-hip ratio (WHR) was significantly higher in the diabetic subjects (P = 0.01). The mean levels of free testosterone (FT) (P = 0.01), dehydroepiandrosterone sulfate (P < 0.04), and estradiol (P = 0.01) (controlled for WHR) were significantly higher in the diabetic subjects; with the statistical outliers removed, the testosterone (P = 0.05) and androstenedione (P = 0.002) levels (controlled for WHR) were also significantly higher in the diabetic subjects. The mean levels of estrone, cortisol, and SHBG were not significantly different. The results were similar in the 10 diabetic subjects treated with diet only. Significant positive correlations (controlled for age and BMI) were observed between FT or testosterone and cholesterol, LDL cholesterol, and blood pressure. CONCLUSIONS - Postmenopausal Hispanic women with type 2 diabetes had both hyperandrogenemia and hyperestrogenemia, and testosterone or FT correlated positively with risk factors for CHD. Hyperandrogenemia may be a link between diabetes and CHD in women.

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