Association du polymorphisme Thr111Ile de la lipase endothéliale avec les paramètres lipidiques du sérum et les complications microvasculaires chez des patients diabétiques de type 2

Translated title of the contribution: Association of endothelial lipase Thr111Ile polymorphism with lipid metabolism and microvascular complications in type 2 diabetic patients

V. Durlach, A. Durlach, I. Movesayan, E. Socquard, C. Zellner, C. Clavel, P. Nazeyrollas, M. J. Malloy, C. R. Pullinger, J. P. Kane, A. Ducasse, B. E. Aouizerat

Research output: Contribution to journalArticle

Abstract

Aim: Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients. Methods: In 396 T2D patients (age: 59.5±10.7 years; BMI: 28.9±5.3kg/m2; HbA1c: 8.2±1.9%), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years). Results: Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy (P=0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95% CI: 1.491-8.239) both initially and at follow-up. Conclusion: The c.584C > T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.

Original languageFrench
Pages (from-to)64-71
Number of pages8
JournalDiabetes and Metabolism
Volume37
Issue number1
DOIs
StatePublished - Feb 2011

Fingerprint

Lipase
Lipid Metabolism
Diabetic Retinopathy
Blood Pressure
HDL Cholesterol
Alleles
Apolipoproteins B
LDL Cholesterol
Lipids
Enzymes
Genes

Keywords

  • Diabetic retinopathy
  • Endothelial lipase
  • Genetics
  • HDL cholesterol
  • Polymorphism of endothelial lipase gene
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Association du polymorphisme Thr111Ile de la lipase endothéliale avec les paramètres lipidiques du sérum et les complications microvasculaires chez des patients diabétiques de type 2. / Durlach, V.; Durlach, A.; Movesayan, I.; Socquard, E.; Zellner, C.; Clavel, C.; Nazeyrollas, P.; Malloy, M. J.; Pullinger, C. R.; Kane, J. P.; Ducasse, A.; Aouizerat, B. E.

In: Diabetes and Metabolism, Vol. 37, No. 1, 02.2011, p. 64-71.

Research output: Contribution to journalArticle

Durlach, V. ; Durlach, A. ; Movesayan, I. ; Socquard, E. ; Zellner, C. ; Clavel, C. ; Nazeyrollas, P. ; Malloy, M. J. ; Pullinger, C. R. ; Kane, J. P. ; Ducasse, A. ; Aouizerat, B. E. / Association du polymorphisme Thr111Ile de la lipase endothéliale avec les paramètres lipidiques du sérum et les complications microvasculaires chez des patients diabétiques de type 2. In: Diabetes and Metabolism. 2011 ; Vol. 37, No. 1. pp. 64-71.
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title = "Association du polymorphisme Thr111Ile de la lipase endoth{\'e}liale avec les param{\`e}tres lipidiques du s{\'e}rum et les complications microvasculaires chez des patients diab{\'e}tiques de type 2",
abstract = "Aim: Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients. Methods: In 396 T2D patients (age: 59.5±10.7 years; BMI: 28.9±5.3kg/m2; HbA1c: 8.2±1.9{\%}), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years). Results: Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy (P=0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95{\%} CI: 1.491-8.239) both initially and at follow-up. Conclusion: The c.584C > T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.",
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T1 - Association du polymorphisme Thr111Ile de la lipase endothéliale avec les paramètres lipidiques du sérum et les complications microvasculaires chez des patients diabétiques de type 2

AU - Durlach, V.

AU - Durlach, A.

AU - Movesayan, I.

AU - Socquard, E.

AU - Zellner, C.

AU - Clavel, C.

AU - Nazeyrollas, P.

AU - Malloy, M. J.

AU - Pullinger, C. R.

AU - Kane, J. P.

AU - Ducasse, A.

AU - Aouizerat, B. E.

PY - 2011/2

Y1 - 2011/2

N2 - Aim: Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients. Methods: In 396 T2D patients (age: 59.5±10.7 years; BMI: 28.9±5.3kg/m2; HbA1c: 8.2±1.9%), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years). Results: Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy (P=0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95% CI: 1.491-8.239) both initially and at follow-up. Conclusion: The c.584C > T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.

AB - Aim: Endothelial lipase (EL) is a key enzyme in lipid metabolism, and a polymorphism in the EL gene may be a candidate for modulating lipid parameters in type 2 diabetic (T2D) patients. Methods: In 396 T2D patients (age: 59.5±10.7 years; BMI: 28.9±5.3kg/m2; HbA1c: 8.2±1.9%), the c.584C>T polymorphism (rs2000813, p.Thr111Ile) was studied in 225 men (frequency of c.584T: 0.351) and 171 women (frequency of c.584T: 0.304). Patients' metabolic parameters, and macrovascular and microvascular complications, were assessed at baseline and at follow-up (mean: 4.2 years). Results: Patients who were homozygous for the minor allele displayed modestly decreased low-density lipoprotein (LDL) cholesterol and raised apolipoprotein B at baseline, and raised systolic blood pressure and high-density lipoprotein (HDL) cholesterol on follow-up. Homozygosity for the minor allele was significantly associated with frequency of retinopathy (P=0.025), with TT homozygous patients more likely to have diabetic retinopathy (OR: 3.505; 95% CI: 1.491-8.239) both initially and at follow-up. Conclusion: The c.584C > T EL polymorphism is associated with a higher risk of diabetic retinopathy that could be linked to modifications in HDL-cholesterol metabolism and blood pressure levels.

KW - Diabetic retinopathy

KW - Endothelial lipase

KW - Genetics

KW - HDL cholesterol

KW - Polymorphism of endothelial lipase gene

KW - Type 2 diabetes mellitus

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