Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

Yu Chen, Fen Wu, Eiko Saito, Yingsong Lin, Minkyo Song, Hung N. Luu, Prakash C. Gupta, Norie Sawada, Akiko Tamakoshi, Xiao Ou Shu, Woon Puay Koh, Yong Bing Xiang, Yasutake Tomata, Kemmyo Sugiyama, Sue K. Park, Keitaro Matsuo, Chisato Nagata, Yumi Sugawara, You Lin Qiao, San Lin YouRenwei Wang, Myung Hee Shin, Wen Harn Pan, Mangesh S. Pednekar, Shoichiro Tsugane, Hui Cai, Jian Min Yuan, Yu Tang Gao, Ichiro Tsuji, Seiki Kanemura, Hidemi Ito, Keiko Wada, Yoon Ok Ahn, Keun Young Yoo, Habibul Ahsan, Kee Seng Chia, Paolo Boffetta, Wei Zheng, Manami Inoue, Daehee Kang, John D. Potter

Research output: Contribution to journalArticle

Abstract

Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.

Original languageEnglish (US)
Pages (from-to)1022-1032
Number of pages11
JournalDiabetologia
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2017

Fingerprint

Type 2 Diabetes Mellitus
Mortality
Neoplasms
Endometrium
Bile Ducts
Prostate
Pancreas
Ovary
Lymphoma
Thyroid Gland
Leukemia
Breast
Kidney
Lung
Liver
Esophageal Neoplasms
Gallbladder
Rectum
Urinary Bladder Neoplasms
Cervix Uteri

Keywords

  • Asia Cohort Consortium
  • Asians
  • Cancer mortality
  • Meta-analysis
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Association between type 2 diabetes and risk of cancer mortality : a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. / Chen, Yu; Wu, Fen; Saito, Eiko; Lin, Yingsong; Song, Minkyo; Luu, Hung N.; Gupta, Prakash C.; Sawada, Norie; Tamakoshi, Akiko; Shu, Xiao Ou; Koh, Woon Puay; Xiang, Yong Bing; Tomata, Yasutake; Sugiyama, Kemmyo; Park, Sue K.; Matsuo, Keitaro; Nagata, Chisato; Sugawara, Yumi; Qiao, You Lin; You, San Lin; Wang, Renwei; Shin, Myung Hee; Pan, Wen Harn; Pednekar, Mangesh S.; Tsugane, Shoichiro; Cai, Hui; Yuan, Jian Min; Gao, Yu Tang; Tsuji, Ichiro; Kanemura, Seiki; Ito, Hidemi; Wada, Keiko; Ahn, Yoon Ok; Yoo, Keun Young; Ahsan, Habibul; Chia, Kee Seng; Boffetta, Paolo; Zheng, Wei; Inoue, Manami; Kang, Daehee; Potter, John D.

In: Diabetologia, Vol. 60, No. 6, 01.06.2017, p. 1022-1032.

Research output: Contribution to journalArticle

Chen, Y, Wu, F, Saito, E, Lin, Y, Song, M, Luu, HN, Gupta, PC, Sawada, N, Tamakoshi, A, Shu, XO, Koh, WP, Xiang, YB, Tomata, Y, Sugiyama, K, Park, SK, Matsuo, K, Nagata, C, Sugawara, Y, Qiao, YL, You, SL, Wang, R, Shin, MH, Pan, WH, Pednekar, MS, Tsugane, S, Cai, H, Yuan, JM, Gao, YT, Tsuji, I, Kanemura, S, Ito, H, Wada, K, Ahn, YO, Yoo, KY, Ahsan, H, Chia, KS, Boffetta, P, Zheng, W, Inoue, M, Kang, D & Potter, JD 2017, 'Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium', Diabetologia, vol. 60, no. 6, pp. 1022-1032. https://doi.org/10.1007/s00125-017-4229-z
Chen, Yu ; Wu, Fen ; Saito, Eiko ; Lin, Yingsong ; Song, Minkyo ; Luu, Hung N. ; Gupta, Prakash C. ; Sawada, Norie ; Tamakoshi, Akiko ; Shu, Xiao Ou ; Koh, Woon Puay ; Xiang, Yong Bing ; Tomata, Yasutake ; Sugiyama, Kemmyo ; Park, Sue K. ; Matsuo, Keitaro ; Nagata, Chisato ; Sugawara, Yumi ; Qiao, You Lin ; You, San Lin ; Wang, Renwei ; Shin, Myung Hee ; Pan, Wen Harn ; Pednekar, Mangesh S. ; Tsugane, Shoichiro ; Cai, Hui ; Yuan, Jian Min ; Gao, Yu Tang ; Tsuji, Ichiro ; Kanemura, Seiki ; Ito, Hidemi ; Wada, Keiko ; Ahn, Yoon Ok ; Yoo, Keun Young ; Ahsan, Habibul ; Chia, Kee Seng ; Boffetta, Paolo ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Potter, John D. / Association between type 2 diabetes and risk of cancer mortality : a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. In: Diabetologia. 2017 ; Vol. 60, No. 6. pp. 1022-1032.
@article{d750668ad5724327948e1acfd36d7bea,
title = "Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium",
abstract = "Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95{\%} CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95{\%} CI 1.26, 1.57), liver (HR 2.05; 95{\%} CI 1.77, 2.38), bile duct (HR 1.41; 95{\%} CI 1.04, 1.92), gallbladder (HR 1.33; 95{\%} CI 1.10, 1.61), pancreas (HR 1.53; 95{\%} CI 1.32, 1.77), breast (HR 1.72; 95{\%} CI 1.34, 2.19), endometrium (HR 2.73; 95{\%} CI 1.53, 4.85), ovary (HR 1.60; 95{\%} CI 1.06, 2.42), prostate (HR 1.41; 95{\%} CI 1.09, 1.82), kidney (HR 1.84; 95{\%} CI 1.28, 2.64) and thyroid (HR 1.99; 95{\%} CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95{\%} CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26{\%} increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.",
keywords = "Asia Cohort Consortium, Asians, Cancer mortality, Meta-analysis, Type 2 diabetes",
author = "Yu Chen and Fen Wu and Eiko Saito and Yingsong Lin and Minkyo Song and Luu, {Hung N.} and Gupta, {Prakash C.} and Norie Sawada and Akiko Tamakoshi and Shu, {Xiao Ou} and Koh, {Woon Puay} and Xiang, {Yong Bing} and Yasutake Tomata and Kemmyo Sugiyama and Park, {Sue K.} and Keitaro Matsuo and Chisato Nagata and Yumi Sugawara and Qiao, {You Lin} and You, {San Lin} and Renwei Wang and Shin, {Myung Hee} and Pan, {Wen Harn} and Pednekar, {Mangesh S.} and Shoichiro Tsugane and Hui Cai and Yuan, {Jian Min} and Gao, {Yu Tang} and Ichiro Tsuji and Seiki Kanemura and Hidemi Ito and Keiko Wada and Ahn, {Yoon Ok} and Yoo, {Keun Young} and Habibul Ahsan and Chia, {Kee Seng} and Paolo Boffetta and Wei Zheng and Manami Inoue and Daehee Kang and Potter, {John D.}",
year = "2017",
month = "6",
day = "1",
doi = "10.1007/s00125-017-4229-z",
language = "English (US)",
volume = "60",
pages = "1022--1032",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Association between type 2 diabetes and risk of cancer mortality

T2 - a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium

AU - Chen, Yu

AU - Wu, Fen

AU - Saito, Eiko

AU - Lin, Yingsong

AU - Song, Minkyo

AU - Luu, Hung N.

AU - Gupta, Prakash C.

AU - Sawada, Norie

AU - Tamakoshi, Akiko

AU - Shu, Xiao Ou

AU - Koh, Woon Puay

AU - Xiang, Yong Bing

AU - Tomata, Yasutake

AU - Sugiyama, Kemmyo

AU - Park, Sue K.

AU - Matsuo, Keitaro

AU - Nagata, Chisato

AU - Sugawara, Yumi

AU - Qiao, You Lin

AU - You, San Lin

AU - Wang, Renwei

AU - Shin, Myung Hee

AU - Pan, Wen Harn

AU - Pednekar, Mangesh S.

AU - Tsugane, Shoichiro

AU - Cai, Hui

AU - Yuan, Jian Min

AU - Gao, Yu Tang

AU - Tsuji, Ichiro

AU - Kanemura, Seiki

AU - Ito, Hidemi

AU - Wada, Keiko

AU - Ahn, Yoon Ok

AU - Yoo, Keun Young

AU - Ahsan, Habibul

AU - Chia, Kee Seng

AU - Boffetta, Paolo

AU - Zheng, Wei

AU - Inoue, Manami

AU - Kang, Daehee

AU - Potter, John D.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.

AB - Aims/hypothesis: The aims of the study were to evaluate the association between type 2 diabetes and the risk of death from any cancer and specific cancers in East and South Asians. Methods: Pooled analyses were conducted of 19 prospective population-based cohorts included in the Asia Cohort Consortium, comprising data from 658,611 East Asians and 112,686 South Asians. HRs were used to compare individuals with diabetes at baseline with those without diabetes for the risk of death from any cancer and from site-specific cancers, including cancers of the oesophagus, stomach, colorectum, colon, rectum, liver, bile duct, pancreas, lung, breast, endometrium, cervix, ovary, prostate, bladder, kidney and thyroid, as well as lymphoma and leukaemia. Results: During a mean follow-up of 12.7 years, 37,343 cancer deaths (36,667 in East Asians and 676 in South Asians) were identified. Baseline diabetes status was statistically significantly associated with an increased risk of death from any cancer (HR 1.26; 95% CI 1.21, 1.31). Significant positive associations with diabetes were observed for cancers of the colorectum (HR 1.41; 95% CI 1.26, 1.57), liver (HR 2.05; 95% CI 1.77, 2.38), bile duct (HR 1.41; 95% CI 1.04, 1.92), gallbladder (HR 1.33; 95% CI 1.10, 1.61), pancreas (HR 1.53; 95% CI 1.32, 1.77), breast (HR 1.72; 95% CI 1.34, 2.19), endometrium (HR 2.73; 95% CI 1.53, 4.85), ovary (HR 1.60; 95% CI 1.06, 2.42), prostate (HR 1.41; 95% CI 1.09, 1.82), kidney (HR 1.84; 95% CI 1.28, 2.64) and thyroid (HR 1.99; 95% CI 1.03, 3.86), as well as lymphoma (HR 1.39; 95% CI 1.04, 1.86). Diabetes was not statistically significantly associated with the risk of death from leukaemia and cancers of the bladder, cervix, oesophagus, stomach and lung. Conclusions/interpretation: Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.

KW - Asia Cohort Consortium

KW - Asians

KW - Cancer mortality

KW - Meta-analysis

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85014523865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014523865&partnerID=8YFLogxK

U2 - 10.1007/s00125-017-4229-z

DO - 10.1007/s00125-017-4229-z

M3 - Article

VL - 60

SP - 1022

EP - 1032

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 6

ER -