Association between Selected Oral Pathogens and Gastric Precancerous Lesions

Christian R. Salazar, Jinghua Sun, Yihong Li, Fritz Francois, Patricia Corby, Guillermo Perez-Perez, Ananda Dasanayake, Zhiheng Pei, Yu Chen

Research output: Contribution to journalArticle

Abstract

We examined whether colonization of selected oral pathogens is associated with gastric precancerous lesions in a cross-sectional study. A total of 119 participants were included, of which 37 were cases of chronic atrophic gastritis, intestinal metaplasia, or dysplasia. An oral examination was performed to measure periodontal indices. Plaque and saliva samples were tested with real-time quantitative PCR for DNA levels of pathogens related to periodontal disease (Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, Actinobacillus actinomycetemcomitans) and dental caries (Streptococcus mutans and S. sobrinus). There were no consistent associations between DNA levels of selected bacterial species and gastric precancerous lesions, although an elevated but non-significant odds ratio (OR) for gastric precancerous lesions was observed in relation to increasing colonization of A. actinomycetemcomitans (OR = 1.36 for one standard deviation increase, 95% Confidence Interval = 0.87-2.12), P. gingivalis (OR = 1.12, 0.67-1.88) and T. denticola (OR = 1.34, 0.83-2.12) measured in plaque. To assess the influence of specific long-term infection, stratified analyses by levels of periodontal indices were conducted. A. actinomycetemcomitans was significantly associated with gastric precancerous lesions (OR = 2.51, 1.13-5.56) among those with ≥ median of percent tooth sites with PD≥3 mm, compared with no association among those below the median (OR = 0.86, 0.43-1.72). A significantly stronger relationship was observed between the cumulative bacterial burden score of periodontal disease-related pathogens and gastric precancerous lesions among those with higher versus lower levels of periodontal disease indices (p-values for interactions: 0.03-0.06). Among individuals with periodontal disease, high levels of colonization of periodontal pathogens are associated with an increased risk of gastric precancerous lesions.

Original languageEnglish (US)
Article numbere51604
JournalPLoS One
Volume8
Issue number1
DOIs
StatePublished - Jan 7 2013

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Pathogens
lesions (animal)
odds ratio
mouth
Actinobacillus actinomycetemcomitans
Stomach
stomach
Odds Ratio
Periodontal Diseases
Aggregatibacter actinomycetemcomitans
Periodontal Index
pathogens
Treponema denticola
Porphyromonas gingivalis
DNA
Streptococcus sobrinus
Streptococcus mutans
dental caries
Atrophic Gastritis
Oral Diagnosis

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Association between Selected Oral Pathogens and Gastric Precancerous Lesions. / Salazar, Christian R.; Sun, Jinghua; Li, Yihong; Francois, Fritz; Corby, Patricia; Perez-Perez, Guillermo; Dasanayake, Ananda; Pei, Zhiheng; Chen, Yu.

In: PLoS One, Vol. 8, No. 1, e51604, 07.01.2013.

Research output: Contribution to journalArticle

Salazar CR, Sun J, Li Y, Francois F, Corby P, Perez-Perez G et al. Association between Selected Oral Pathogens and Gastric Precancerous Lesions. PLoS One. 2013 Jan 7;8(1). e51604. https://doi.org/10.1371/journal.pone.0051604
Salazar, Christian R. ; Sun, Jinghua ; Li, Yihong ; Francois, Fritz ; Corby, Patricia ; Perez-Perez, Guillermo ; Dasanayake, Ananda ; Pei, Zhiheng ; Chen, Yu. / Association between Selected Oral Pathogens and Gastric Precancerous Lesions. In: PLoS One. 2013 ; Vol. 8, No. 1.
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