Association between periodontitis and spontaneous abortion

A case-control study

Anchana Chanomethaporn, Anek Chayasadom, Nawarat Wara-Aswapati, Kiattisak Kongwattanakul, Waraporn Suwannarong, Kamonchanok Tangwanichgapong, Gunniga Sumanonta, Oranart Matangkasombut, Ananda Dasanayake, Waranuch Pitiphat

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Spontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion. METHODS: We conducted a matched case-control study in two tertiary hospitals in Khon Kaen, Thailand. Cases were 85 women with spontaneous abortion at <20 weeks of gestation matched to 85 controls on age, gestational age, and hospital. Full-mouth periodontal examinations were performed. Periodontitis was defined as at least one site with probing depth ≥5 mm and clinical attachment level ≥2 mm at the same site. Subgingival plaque samples were collected to determine the levels of Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum using real time polymerase chain reaction. RESULTS: The cases were significantly more likely to have periodontitis (50.6%) than the controls (21.2%; P = 0.007). Conditional logistic regression revealed a crude odds ratio (OR) of 4.1 for the association between periodontitis and spontaneous abortion (95% confidence interval [CI] = 1.9-8.9, P = 0.001). The OR decreased, but was still significant, after controlling for previous miscarriage (OR = 3.3, 95% CI = 1.4-7.8, P = 0.006). There was no significant association between the levels of periodontopathic bacteria and spontaneous abortion. Increased levels of P. gingivalis and F. nucleatum were associated with periodontitis in both case and control groups. Association between increased T. forsythia levels and periodontitis was observed only in the case women. CONCLUSIONS: Periodontitis was more common in women with spontaneous abortions as compared with matched controls. Levels of periodontopathic bacteria was not associated with spontaneous abortion in this population.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalJournal of periodontology
Volume90
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Periodontitis
Spontaneous Abortion
Case-Control Studies
Fusobacterium nucleatum
Porphyromonas gingivalis
Odds Ratio
Bacteria
Confidence Intervals
Pregnancy Complications
Thailand
Tertiary Care Centers
Gestational Age
Mouth
Real-Time Polymerase Chain Reaction
Logistic Models
Pregnancy
Control Groups

Keywords

  • bacteria
  • case-control study
  • periodontitis
  • real-time polymerase chain reaction
  • spontaneous abortion

ASJC Scopus subject areas

  • Periodontics

Cite this

Chanomethaporn, A., Chayasadom, A., Wara-Aswapati, N., Kongwattanakul, K., Suwannarong, W., Tangwanichgapong, K., ... Pitiphat, W. (2019). Association between periodontitis and spontaneous abortion: A case-control study. Journal of periodontology, 90(4), 381-390. https://doi.org/10.1002/JPER.18-0174

Association between periodontitis and spontaneous abortion : A case-control study. / Chanomethaporn, Anchana; Chayasadom, Anek; Wara-Aswapati, Nawarat; Kongwattanakul, Kiattisak; Suwannarong, Waraporn; Tangwanichgapong, Kamonchanok; Sumanonta, Gunniga; Matangkasombut, Oranart; Dasanayake, Ananda; Pitiphat, Waranuch.

In: Journal of periodontology, Vol. 90, No. 4, 01.04.2019, p. 381-390.

Research output: Contribution to journalArticle

Chanomethaporn, A, Chayasadom, A, Wara-Aswapati, N, Kongwattanakul, K, Suwannarong, W, Tangwanichgapong, K, Sumanonta, G, Matangkasombut, O, Dasanayake, A & Pitiphat, W 2019, 'Association between periodontitis and spontaneous abortion: A case-control study', Journal of periodontology, vol. 90, no. 4, pp. 381-390. https://doi.org/10.1002/JPER.18-0174
Chanomethaporn A, Chayasadom A, Wara-Aswapati N, Kongwattanakul K, Suwannarong W, Tangwanichgapong K et al. Association between periodontitis and spontaneous abortion: A case-control study. Journal of periodontology. 2019 Apr 1;90(4):381-390. https://doi.org/10.1002/JPER.18-0174
Chanomethaporn, Anchana ; Chayasadom, Anek ; Wara-Aswapati, Nawarat ; Kongwattanakul, Kiattisak ; Suwannarong, Waraporn ; Tangwanichgapong, Kamonchanok ; Sumanonta, Gunniga ; Matangkasombut, Oranart ; Dasanayake, Ananda ; Pitiphat, Waranuch. / Association between periodontitis and spontaneous abortion : A case-control study. In: Journal of periodontology. 2019 ; Vol. 90, No. 4. pp. 381-390.
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abstract = "BACKGROUND: Spontaneous abortion, or miscarriage, is a complication of pregnancy which can severely affect women both physically and psychologically. We investigated the associations of periodontitis and periodontopathic bacteria with spontaneous abortion. METHODS: We conducted a matched case-control study in two tertiary hospitals in Khon Kaen, Thailand. Cases were 85 women with spontaneous abortion at <20 weeks of gestation matched to 85 controls on age, gestational age, and hospital. Full-mouth periodontal examinations were performed. Periodontitis was defined as at least one site with probing depth ≥5 mm and clinical attachment level ≥2 mm at the same site. Subgingival plaque samples were collected to determine the levels of Porphyromonas gingivalis, Tannerella forsythia, and Fusobacterium nucleatum using real time polymerase chain reaction. RESULTS: The cases were significantly more likely to have periodontitis (50.6{\%}) than the controls (21.2{\%}; P = 0.007). Conditional logistic regression revealed a crude odds ratio (OR) of 4.1 for the association between periodontitis and spontaneous abortion (95{\%} confidence interval [CI] = 1.9-8.9, P = 0.001). The OR decreased, but was still significant, after controlling for previous miscarriage (OR = 3.3, 95{\%} CI = 1.4-7.8, P = 0.006). There was no significant association between the levels of periodontopathic bacteria and spontaneous abortion. Increased levels of P. gingivalis and F. nucleatum were associated with periodontitis in both case and control groups. Association between increased T. forsythia levels and periodontitis was observed only in the case women. CONCLUSIONS: Periodontitis was more common in women with spontaneous abortions as compared with matched controls. Levels of periodontopathic bacteria was not associated with spontaneous abortion in this population.",
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