Association between number of children and carotid intima-media thickness in Bangladesh

Vylyny Chat, Fen Wu, Ryan T. Demmer, Faruque Parvez, Alauddin Ahmed, Mahbub Eunus, Rabiul Hasan, Jabun Nahar, Ishrat Shaheen, Golam Sarwar, Moise Desvarieux, Habibul Ahsan, Yu Chen

Research output: Contribution to journalArticle

Abstract

Previous studies on the association between number of children and carotid intima-media thickness (cIMT) were limited to Western populations. Pregnancy in women is associated with physiologic changes that may influence the risk of cardiovascular disease. Comparing the association between number of children and cIMT in men and women can provide insights on whether the association may be due to pregnancy. We investigated the association between number of children and cIMT among 718 female (mean age 37.5 years) and 417 male participants (mean age 41.3 years), randomly selected from the Health Effect of Arsenic Longitudinal Study (HEALS), a population-based cohort study in Bangladesh. Multivariate linear regression was used to assess the association and to control for education attainment, history of diabetes, age, smoking, betel use, BMI, systolic blood pressure, and diastolic blood pressure. The average number of children was 4.43 for women and 3.74 for men. There were no nulliparous women. We observed a positive association between number of children and cIMT in women. Mean cIMT increased by 4.5 μm (95% CI, 0.8–8.1) per increment of one birth (P = 0.02). Compared to women with two children, cIMT in women with 4 children and 5 children was 23.6μm (95%CI, 2.6–44.7; P = 0.03) and 25.1 μm (95%CI, 3.5–46.6; P = 0.02) greater, respectively. The association was not modified by BMI, SBP, betel use or age. Data in men showed no evidence of association (P = 0.4). The finding suggests a role of high parity in atherosclerosis in women of a low-income, high parity population.

Original languageEnglish (US)
Article numbere0208148
JournalPLoS One
Volume13
Issue number11
DOIs
StatePublished - Nov 1 2018

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Carotid Intima-Media Thickness
Bangladesh
Blood pressure
Arsenic
Medical problems
Linear regression
Education
Health
betel
Blood Pressure
parity (reproduction)
Parity
pregnancy
Pregnancy
diastolic blood pressure
systolic blood pressure
longitudinal studies
arsenic
atherosclerosis
cohort studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Association between number of children and carotid intima-media thickness in Bangladesh. / Chat, Vylyny; Wu, Fen; Demmer, Ryan T.; Parvez, Faruque; Ahmed, Alauddin; Eunus, Mahbub; Hasan, Rabiul; Nahar, Jabun; Shaheen, Ishrat; Sarwar, Golam; Desvarieux, Moise; Ahsan, Habibul; Chen, Yu.

In: PLoS One, Vol. 13, No. 11, e0208148, 01.11.2018.

Research output: Contribution to journalArticle

Chat, V, Wu, F, Demmer, RT, Parvez, F, Ahmed, A, Eunus, M, Hasan, R, Nahar, J, Shaheen, I, Sarwar, G, Desvarieux, M, Ahsan, H & Chen, Y 2018, 'Association between number of children and carotid intima-media thickness in Bangladesh', PLoS One, vol. 13, no. 11, e0208148. https://doi.org/10.1371/journal.pone.0208148
Chat, Vylyny ; Wu, Fen ; Demmer, Ryan T. ; Parvez, Faruque ; Ahmed, Alauddin ; Eunus, Mahbub ; Hasan, Rabiul ; Nahar, Jabun ; Shaheen, Ishrat ; Sarwar, Golam ; Desvarieux, Moise ; Ahsan, Habibul ; Chen, Yu. / Association between number of children and carotid intima-media thickness in Bangladesh. In: PLoS One. 2018 ; Vol. 13, No. 11.
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