Association between Helicobacter pylori and mortality in the NHANES III study

Yu Chen, Stephanie Segers, Martin J. Blaser

Research output: Contribution to journalArticle

Abstract

Objective Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. Design We conducted prospective cohort analyses in a nationally representative sample of 9895 participants enrolled in the National Health and Nutrition Examination Survey III to assess the association of H pylori status with all-cause and cause-specific mortality. Analyses for the association of H pylori cagA positivity with mortality were conducted in 7384 subjects with data on H pylori cagA status. Results In older people (>40.1 years), H pylori was not associated with all-cause mortality (HR 1.00; 95% CI 0.84 to 1.18). There was an inverse association of H pylori status with stroke mortality (HR 0.69; 95% CI 0.44 to 1.08), and the inverse association was stronger for H pylori cagA positivity, with the HR of 0.45 (95% CI 0.27 to 0.76). H pylori was also strongly positively related to gastric cancer mortality. After we adjusted p values using the Benjamini-Hochberg false discovery rate method to account for multiple comparisons, these associations remained, and H pylori status was not related to other outcomes. Conclusions Our findings suggest that H pylori has a mixed role in human health, but is not a major risk factor for all-cause mortality.

Original languageEnglish (US)
Pages (from-to)1262-1269
Number of pages8
JournalGut
Volume62
Issue number9
DOIs
StatePublished - Sep 2013

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Nutrition Surveys
Pylorus
Helicobacter pylori
Mortality
Health
Stomach Neoplasms
Cohort Studies
Stroke

ASJC Scopus subject areas

  • Gastroenterology

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Association between Helicobacter pylori and mortality in the NHANES III study. / Chen, Yu; Segers, Stephanie; Blaser, Martin J.

In: Gut, Vol. 62, No. 9, 09.2013, p. 1262-1269.

Research output: Contribution to journalArticle

Chen, Yu ; Segers, Stephanie ; Blaser, Martin J. / Association between Helicobacter pylori and mortality in the NHANES III study. In: Gut. 2013 ; Vol. 62, No. 9. pp. 1262-1269.
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