Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population

Kazuo Eguchi, Bernadette Boden-Albala, Zhezhen Jin, Tatjana Rundek, Ralph L. Sacco, Shunichi Homma, Marco R. Di Tullio

Research output: Contribution to journalArticle

Abstract

It is still controversial whether type 2 diabetes mellitus (T2DM) is associated with increased left ventricular (LV) mass independent of body size. We tested the hypothesis that T2DM is independently associated with LV mass in a multiethnic cohort. In the Northern Manhattan Study (NOMAS) cohort sample, a total of 1,932 subjects (67.9 ± 9.6 years, 769 men and 1,163 women, 443 with DM and 1,489 without DM) were studied by transthoracic echocardiography, and LV mass was calculated. LV hypertrophy was defined as the upper quartile of LV mass. Multivariable models were used to assess the association of T2DM with LV mass after adjusting for age, gender, race, body mass index (BMI), systolic blood pressure, education, history of coronary artery disease, physical activity, and alcohol consumption. LV mass (189 ± 60 vs 174 ± 59 g, p <0.0001), BMI, and systolic blood pressure were higher in the DM group than in the non-DM group, whereas age and gender distributions were similar between groups. In multivariable analysis, T2DM was independently associated with increased LV mass (p = 0.03). Presence of T2DM was associated with increased risk of LV hypertrophy (adjusted odds ratio 1.46, 95% confidence interval 1.13 to 1.88, p = 0.004). Although no interactions were observed between T2DM and BMI on LV hypertrophy (p = 0.6), there was a significant interaction between T2DM and waist circumference on LV hypertrophy (p = 0.01). In conclusion, T2DM was independently associated with increased LV hypertrophy independent of various covariates in this multiethnic sample. Presence of T2DM increased the risk of LV hypertrophy by about 1.5-fold, and it possibly interacted with central obesity.

Original languageEnglish (US)
Pages (from-to)1787-1791
Number of pages5
JournalAmerican Journal of Cardiology
Volume101
Issue number12
DOIs
StatePublished - Jun 15 2008

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Left Ventricular Hypertrophy
Type 2 Diabetes Mellitus
Diabetes Mellitus
Population
Blood Pressure
Body Mass Index
Abdominal Obesity
Age Distribution
Body Size
Waist Circumference
Alcohol Drinking
Echocardiography
Coronary Artery Disease
Cohort Studies
Odds Ratio
Confidence Intervals
Exercise
Education

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population. / Eguchi, Kazuo; Boden-Albala, Bernadette; Jin, Zhezhen; Rundek, Tatjana; Sacco, Ralph L.; Homma, Shunichi; Di Tullio, Marco R.

In: American Journal of Cardiology, Vol. 101, No. 12, 15.06.2008, p. 1787-1791.

Research output: Contribution to journalArticle

Eguchi, Kazuo ; Boden-Albala, Bernadette ; Jin, Zhezhen ; Rundek, Tatjana ; Sacco, Ralph L. ; Homma, Shunichi ; Di Tullio, Marco R. / Association Between Diabetes Mellitus and Left Ventricular Hypertrophy in a Multiethnic Population. In: American Journal of Cardiology. 2008 ; Vol. 101, No. 12. pp. 1787-1791.
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