Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

Rohit Loomba, Maria Abraham, Aynur Unalp, Laura Wilson, Joel Lavine, Ed Doo, Nathan M Bass, Bradley Aouizerat, Nonalcoholic Steatohepatitis Clinical Research Network

Research output: Contribution to journalArticle

Abstract

UNLABELLED: Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63% women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m(2) , were included. Thirty percent had DM, and 56% had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95% confidence interval [CI]: 1.37-2.73; P <0.001) and 1.48 (95% CI: 1.11-1.97; P = 0.01) and any fibrosis with an OR of 3.31 (95% CI: 2.26-4.85; P < 0.001) and 1.66 (95% CI: 1.25-2.20; P < 0.001), respectively. When the models were adjusted for age, sex, BMI, ethnicity, and metabolic traits, the association between diabetes and family history of DM with NASH showed an increased adjusted OR of 1.76 (95% CI: 1.13-2.72; P < 0.001) and 1.34 (95% CI: 0.99-1.81; P = 0.06), respectively, and with any fibrosis with a significant adjusted OR of 2.57 (95% CI: 1.61-4.11; P < 0.0001) and 1.38 (95% CI: 1.02-1.87; P = 0.04), respectively. After excluding patients with personal history of diabetes, family history of DM was significantly associated with the presence of NASH and any fibrosis with an adjusted OR of 1.51 (95% CI: 1.01-2.25; P = 0.04) and 1.49 (95% CI: 1.01-2.20; P = 0.04), respectively.

CONCLUSIONS: Diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis. Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD.

Original languageEnglish (US)
Pages (from-to)943-51
Number of pages9
JournalHepatology
Volume56
Issue number3
DOIs
StatePublished - Sep 2012

Fingerprint

Fibrosis
Confidence Intervals
Diabetes Mellitus
Odds Ratio
Body Mass Index
Non-alcoholic Fatty Liver Disease
Insulin Resistance
Cross-Sectional Studies
Databases

Keywords

  • Cross-Sectional Studies
  • Diabetes Complications
  • Diabetes Mellitus
  • Fatty Liver
  • Female
  • Humans
  • Liver Cirrhosis
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease
  • Prospective Studies
  • Risk Factors

Cite this

Loomba, R., Abraham, M., Unalp, A., Wilson, L., Lavine, J., Doo, E., ... Nonalcoholic Steatohepatitis Clinical Research Network (2012). Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. Hepatology, 56(3), 943-51. https://doi.org/10.1002/hep.25772

Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. / Loomba, Rohit; Abraham, Maria; Unalp, Aynur; Wilson, Laura; Lavine, Joel; Doo, Ed; Bass, Nathan M; Aouizerat, Bradley; Nonalcoholic Steatohepatitis Clinical Research Network.

In: Hepatology, Vol. 56, No. 3, 09.2012, p. 943-51.

Research output: Contribution to journalArticle

Loomba, R, Abraham, M, Unalp, A, Wilson, L, Lavine, J, Doo, E, Bass, NM, Aouizerat, B & Nonalcoholic Steatohepatitis Clinical Research Network 2012, 'Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis', Hepatology, vol. 56, no. 3, pp. 943-51. https://doi.org/10.1002/hep.25772
Loomba, Rohit ; Abraham, Maria ; Unalp, Aynur ; Wilson, Laura ; Lavine, Joel ; Doo, Ed ; Bass, Nathan M ; Aouizerat, Bradley ; Nonalcoholic Steatohepatitis Clinical Research Network. / Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis. In: Hepatology. 2012 ; Vol. 56, No. 3. pp. 943-51.
@article{3cda47ea2c4f4bae8fda64b2f77f5692,
title = "Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis",
abstract = "UNLABELLED: Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63{\%} women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m(2) , were included. Thirty percent had DM, and 56{\%} had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95{\%} confidence interval [CI]: 1.37-2.73; P <0.001) and 1.48 (95{\%} CI: 1.11-1.97; P = 0.01) and any fibrosis with an OR of 3.31 (95{\%} CI: 2.26-4.85; P < 0.001) and 1.66 (95{\%} CI: 1.25-2.20; P < 0.001), respectively. When the models were adjusted for age, sex, BMI, ethnicity, and metabolic traits, the association between diabetes and family history of DM with NASH showed an increased adjusted OR of 1.76 (95{\%} CI: 1.13-2.72; P < 0.001) and 1.34 (95{\%} CI: 0.99-1.81; P = 0.06), respectively, and with any fibrosis with a significant adjusted OR of 2.57 (95{\%} CI: 1.61-4.11; P < 0.0001) and 1.38 (95{\%} CI: 1.02-1.87; P = 0.04), respectively. After excluding patients with personal history of diabetes, family history of DM was significantly associated with the presence of NASH and any fibrosis with an adjusted OR of 1.51 (95{\%} CI: 1.01-2.25; P = 0.04) and 1.49 (95{\%} CI: 1.01-2.20; P = 0.04), respectively.CONCLUSIONS: Diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis. Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD.",
keywords = "Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Fatty Liver, Female, Humans, Liver Cirrhosis, Male, Middle Aged, Non-alcoholic Fatty Liver Disease, Prospective Studies, Risk Factors",
author = "Rohit Loomba and Maria Abraham and Aynur Unalp and Laura Wilson and Joel Lavine and Ed Doo and Bass, {Nathan M} and Bradley Aouizerat and {Nonalcoholic Steatohepatitis Clinical Research Network}",
note = "Copyright {\circledC} 2012 American Association for the Study of Liver Diseases.",
year = "2012",
month = "9",
doi = "10.1002/hep.25772",
language = "English (US)",
volume = "56",
pages = "943--51",
journal = "Hepatology",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

TY - JOUR

T1 - Association between diabetes, family history of diabetes, and risk of nonalcoholic steatohepatitis and fibrosis

AU - Loomba, Rohit

AU - Abraham, Maria

AU - Unalp, Aynur

AU - Wilson, Laura

AU - Lavine, Joel

AU - Doo, Ed

AU - Bass, Nathan M

AU - Aouizerat, Bradley

AU - Nonalcoholic Steatohepatitis Clinical Research Network

N1 - Copyright © 2012 American Association for the Study of Liver Diseases.

PY - 2012/9

Y1 - 2012/9

N2 - UNLABELLED: Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63% women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m(2) , were included. Thirty percent had DM, and 56% had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95% confidence interval [CI]: 1.37-2.73; P <0.001) and 1.48 (95% CI: 1.11-1.97; P = 0.01) and any fibrosis with an OR of 3.31 (95% CI: 2.26-4.85; P < 0.001) and 1.66 (95% CI: 1.25-2.20; P < 0.001), respectively. When the models were adjusted for age, sex, BMI, ethnicity, and metabolic traits, the association between diabetes and family history of DM with NASH showed an increased adjusted OR of 1.76 (95% CI: 1.13-2.72; P < 0.001) and 1.34 (95% CI: 0.99-1.81; P = 0.06), respectively, and with any fibrosis with a significant adjusted OR of 2.57 (95% CI: 1.61-4.11; P < 0.0001) and 1.38 (95% CI: 1.02-1.87; P = 0.04), respectively. After excluding patients with personal history of diabetes, family history of DM was significantly associated with the presence of NASH and any fibrosis with an adjusted OR of 1.51 (95% CI: 1.01-2.25; P = 0.04) and 1.49 (95% CI: 1.01-2.20; P = 0.04), respectively.CONCLUSIONS: Diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis. Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD.

AB - UNLABELLED: Previous studies have shown familial aggregation of insulin resistance and nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to examine whether family history of diabetes mellitus (DM) is associated with nonalcoholic steatohepatitis (NASH) and fibrosis in patients with NAFLD. This was a cross-sectional analysis in participants of the NAFLD Database study and PIVENS trial who had available data on family history of DM. One thousand and sixty-nine patients (63% women), with mean age of 49.6 (± 11.8) years and body mass index (BMI) of 34.2 (± 6.4) kg/m(2) , were included. Thirty percent had DM, and 56% had a family history of DM. Both personal history of DM and family history of DM were significantly associated with NASH, with an odds ratio (OR) of 1.93 (95% confidence interval [CI]: 1.37-2.73; P <0.001) and 1.48 (95% CI: 1.11-1.97; P = 0.01) and any fibrosis with an OR of 3.31 (95% CI: 2.26-4.85; P < 0.001) and 1.66 (95% CI: 1.25-2.20; P < 0.001), respectively. When the models were adjusted for age, sex, BMI, ethnicity, and metabolic traits, the association between diabetes and family history of DM with NASH showed an increased adjusted OR of 1.76 (95% CI: 1.13-2.72; P < 0.001) and 1.34 (95% CI: 0.99-1.81; P = 0.06), respectively, and with any fibrosis with a significant adjusted OR of 2.57 (95% CI: 1.61-4.11; P < 0.0001) and 1.38 (95% CI: 1.02-1.87; P = 0.04), respectively. After excluding patients with personal history of diabetes, family history of DM was significantly associated with the presence of NASH and any fibrosis with an adjusted OR of 1.51 (95% CI: 1.01-2.25; P = 0.04) and 1.49 (95% CI: 1.01-2.20; P = 0.04), respectively.CONCLUSIONS: Diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis. Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD.

KW - Cross-Sectional Studies

KW - Diabetes Complications

KW - Diabetes Mellitus

KW - Fatty Liver

KW - Female

KW - Humans

KW - Liver Cirrhosis

KW - Male

KW - Middle Aged

KW - Non-alcoholic Fatty Liver Disease

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1002/hep.25772

DO - 10.1002/hep.25772

M3 - Article

VL - 56

SP - 943

EP - 951

JO - Hepatology

JF - Hepatology

SN - 0270-9139

IS - 3

ER -