Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh

Tyler R. McClintock, Faruque Parvez, Fen Wu, Weijia Wang, Tariqul Islam, Alauddin Ahmed, Ishrat Shaheen, Golam Sarwar, Ryan T. Demmer, Moise Desvarieux, Habibul Ahsan, Yu Chen

Research output: Contribution to journalArticle

Abstract

Background: Areca nut, more commonly known as betel nut, is the fourth most commonly used addictive substance in the world. Though recent evidence suggests it may play a role in the development of cardiovascular disease, no studies have investigated whether betel nut use is related to subclinical atherosclerosis. Methods: We evaluated the association between betel nut use and subclinical atherosclerosis in 1206 participants randomly sampled from the Health Effects of Arsenic Longitudinal Study (HEALS). Frequency and duration of betel nut use were assessed at baseline, and carotid IMT was measured on average 6.65 years after baseline. Results: A positive association was observed between duration and cumulative exposure (function of duration and frequency) of betel nut use and IMT, with above-median use for duration (7 or more years) and cumulative exposure (30 or more quid-years) corresponding to a 19.1 μm [95% confidence interval (CI): 5.3-32.8; P_0.01] and 16.8 μm (95% CI: 2.9-30.8; P<0.05) higher IMT in an adjusted model, respectively. This association was more pronounced in men [32.8 μm (95% CI: 10.0-55.7) and 30.9 μm (95% CI: 7.4-54.2)]. There was a synergy between cigarette smoking and above-median betel use such that the joint exposure was associated with a 42.4 μm (95% CI: 21.6-63.2; P_0.01) difference in IMT.Conclusion: Betel nut use at long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid IMT. This effect is especially pronounced among men and cigarette smokers.

Original languageEnglish (US)
Article numberdyu009
Pages (from-to)1174-1182
Number of pages9
JournalInternational Journal of Epidemiology
Volume43
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Areca
Carotid Intima-Media Thickness
Bangladesh
Mastication
Confidence Intervals
Atherosclerosis
Nuts
Arsenic
Tobacco Products
Longitudinal Studies
Cardiovascular Diseases
Joints
Smoking
Health

Keywords

  • Areca nut
  • Bangladesh
  • Betel nut
  • Cardiovascular disease
  • Carotid intima-media thickness

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. / McClintock, Tyler R.; Parvez, Faruque; Wu, Fen; Wang, Weijia; Islam, Tariqul; Ahmed, Alauddin; Shaheen, Ishrat; Sarwar, Golam; Demmer, Ryan T.; Desvarieux, Moise; Ahsan, Habibul; Chen, Yu.

In: International Journal of Epidemiology, Vol. 43, No. 4, dyu009, 2014, p. 1174-1182.

Research output: Contribution to journalArticle

McClintock, TR, Parvez, F, Wu, F, Wang, W, Islam, T, Ahmed, A, Shaheen, I, Sarwar, G, Demmer, RT, Desvarieux, M, Ahsan, H & Chen, Y 2014, 'Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh', International Journal of Epidemiology, vol. 43, no. 4, dyu009, pp. 1174-1182. https://doi.org/10.1093/ije/dyu009
McClintock, Tyler R. ; Parvez, Faruque ; Wu, Fen ; Wang, Weijia ; Islam, Tariqul ; Ahmed, Alauddin ; Shaheen, Ishrat ; Sarwar, Golam ; Demmer, Ryan T. ; Desvarieux, Moise ; Ahsan, Habibul ; Chen, Yu. / Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh. In: International Journal of Epidemiology. 2014 ; Vol. 43, No. 4. pp. 1174-1182.
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abstract = "Background: Areca nut, more commonly known as betel nut, is the fourth most commonly used addictive substance in the world. Though recent evidence suggests it may play a role in the development of cardiovascular disease, no studies have investigated whether betel nut use is related to subclinical atherosclerosis. Methods: We evaluated the association between betel nut use and subclinical atherosclerosis in 1206 participants randomly sampled from the Health Effects of Arsenic Longitudinal Study (HEALS). Frequency and duration of betel nut use were assessed at baseline, and carotid IMT was measured on average 6.65 years after baseline. Results: A positive association was observed between duration and cumulative exposure (function of duration and frequency) of betel nut use and IMT, with above-median use for duration (7 or more years) and cumulative exposure (30 or more quid-years) corresponding to a 19.1 μm [95{\%} confidence interval (CI): 5.3-32.8; P_0.01] and 16.8 μm (95{\%} CI: 2.9-30.8; P<0.05) higher IMT in an adjusted model, respectively. This association was more pronounced in men [32.8 μm (95{\%} CI: 10.0-55.7) and 30.9 μm (95{\%} CI: 7.4-54.2)]. There was a synergy between cigarette smoking and above-median betel use such that the joint exposure was associated with a 42.4 μm (95{\%} CI: 21.6-63.2; P_0.01) difference in IMT.Conclusion: Betel nut use at long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid IMT. This effect is especially pronounced among men and cigarette smokers.",
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T1 - Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh

AU - McClintock, Tyler R.

AU - Parvez, Faruque

AU - Wu, Fen

AU - Wang, Weijia

AU - Islam, Tariqul

AU - Ahmed, Alauddin

AU - Shaheen, Ishrat

AU - Sarwar, Golam

AU - Demmer, Ryan T.

AU - Desvarieux, Moise

AU - Ahsan, Habibul

AU - Chen, Yu

PY - 2014

Y1 - 2014

N2 - Background: Areca nut, more commonly known as betel nut, is the fourth most commonly used addictive substance in the world. Though recent evidence suggests it may play a role in the development of cardiovascular disease, no studies have investigated whether betel nut use is related to subclinical atherosclerosis. Methods: We evaluated the association between betel nut use and subclinical atherosclerosis in 1206 participants randomly sampled from the Health Effects of Arsenic Longitudinal Study (HEALS). Frequency and duration of betel nut use were assessed at baseline, and carotid IMT was measured on average 6.65 years after baseline. Results: A positive association was observed between duration and cumulative exposure (function of duration and frequency) of betel nut use and IMT, with above-median use for duration (7 or more years) and cumulative exposure (30 or more quid-years) corresponding to a 19.1 μm [95% confidence interval (CI): 5.3-32.8; P_0.01] and 16.8 μm (95% CI: 2.9-30.8; P<0.05) higher IMT in an adjusted model, respectively. This association was more pronounced in men [32.8 μm (95% CI: 10.0-55.7) and 30.9 μm (95% CI: 7.4-54.2)]. There was a synergy between cigarette smoking and above-median betel use such that the joint exposure was associated with a 42.4 μm (95% CI: 21.6-63.2; P_0.01) difference in IMT.Conclusion: Betel nut use at long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid IMT. This effect is especially pronounced among men and cigarette smokers.

AB - Background: Areca nut, more commonly known as betel nut, is the fourth most commonly used addictive substance in the world. Though recent evidence suggests it may play a role in the development of cardiovascular disease, no studies have investigated whether betel nut use is related to subclinical atherosclerosis. Methods: We evaluated the association between betel nut use and subclinical atherosclerosis in 1206 participants randomly sampled from the Health Effects of Arsenic Longitudinal Study (HEALS). Frequency and duration of betel nut use were assessed at baseline, and carotid IMT was measured on average 6.65 years after baseline. Results: A positive association was observed between duration and cumulative exposure (function of duration and frequency) of betel nut use and IMT, with above-median use for duration (7 or more years) and cumulative exposure (30 or more quid-years) corresponding to a 19.1 μm [95% confidence interval (CI): 5.3-32.8; P_0.01] and 16.8 μm (95% CI: 2.9-30.8; P<0.05) higher IMT in an adjusted model, respectively. This association was more pronounced in men [32.8 μm (95% CI: 10.0-55.7) and 30.9 μm (95% CI: 7.4-54.2)]. There was a synergy between cigarette smoking and above-median betel use such that the joint exposure was associated with a 42.4 μm (95% CI: 21.6-63.2; P_0.01) difference in IMT.Conclusion: Betel nut use at long duration or high cumulative exposure levels is associated with subclinical atherosclerosis as manifested through carotid IMT. This effect is especially pronounced among men and cigarette smokers.

KW - Areca nut

KW - Bangladesh

KW - Betel nut

KW - Cardiovascular disease

KW - Carotid intima-media thickness

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