Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers

Fen Wu, Farzana Jasmine, Muhammad G. Kibriya, Mengling Liu, Oktawia Wójcik, Faruque Parvez, Ronald Rahaman, Shantanu Roy, Rachelle Paul-Brutus, Stephanie Segers, Vesna Slavkovich, Tariqul Islam, Diane Levy, Jacob L. Mey, Alexander Van Geen, Joseph H. Graziano, Habibul Ahsan, Yu Chen

Research output: Contribution to journalArticle

Abstract

The authors conducted a cross-sectional study to assess the relation between arsenic exposure fromdrinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95%confidence interval: 1.01, 1.03) and 1.04 (95%confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher bodymass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1252-1261
Number of pages10
JournalAmerican Journal of Epidemiology
Volume175
Issue number12
DOIs
StatePublished - Jun 15 2012

Fingerprint

Arsenic
Drinking Water
Blood Vessels
Plasminogen Activator Inhibitor 1
Water
Body Mass Index
Confidence Intervals
Inflammation
E-Selectin
Bangladesh
Matrix Metalloproteinase 9
Intercellular Adhesion Molecule-1
Peroxidase
Longitudinal Studies
Creatinine
Cardiovascular Diseases
Cross-Sectional Studies
Health

Keywords

  • Arsenic
  • Bangladesh
  • Cardiovascular disease
  • Cross-sectional studies
  • Environmental exposure
  • Inflammation

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers. / Wu, Fen; Jasmine, Farzana; Kibriya, Muhammad G.; Liu, Mengling; Wójcik, Oktawia; Parvez, Faruque; Rahaman, Ronald; Roy, Shantanu; Paul-Brutus, Rachelle; Segers, Stephanie; Slavkovich, Vesna; Islam, Tariqul; Levy, Diane; Mey, Jacob L.; Van Geen, Alexander; Graziano, Joseph H.; Ahsan, Habibul; Chen, Yu.

In: American Journal of Epidemiology, Vol. 175, No. 12, 15.06.2012, p. 1252-1261.

Research output: Contribution to journalArticle

Wu, F, Jasmine, F, Kibriya, MG, Liu, M, Wójcik, O, Parvez, F, Rahaman, R, Roy, S, Paul-Brutus, R, Segers, S, Slavkovich, V, Islam, T, Levy, D, Mey, JL, Van Geen, A, Graziano, JH, Ahsan, H & Chen, Y 2012, 'Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers', American Journal of Epidemiology, vol. 175, no. 12, pp. 1252-1261. https://doi.org/10.1093/aje/kwr464
Wu, Fen ; Jasmine, Farzana ; Kibriya, Muhammad G. ; Liu, Mengling ; Wójcik, Oktawia ; Parvez, Faruque ; Rahaman, Ronald ; Roy, Shantanu ; Paul-Brutus, Rachelle ; Segers, Stephanie ; Slavkovich, Vesna ; Islam, Tariqul ; Levy, Diane ; Mey, Jacob L. ; Van Geen, Alexander ; Graziano, Joseph H. ; Ahsan, Habibul ; Chen, Yu. / Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers. In: American Journal of Epidemiology. 2012 ; Vol. 175, No. 12. pp. 1252-1261.
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abstract = "The authors conducted a cross-sectional study to assess the relation between arsenic exposure fromdrinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95{\%}confidence interval: 1.01, 1.03) and 1.04 (95{\%}confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher bodymass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.",
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AU - Parvez, Faruque

AU - Rahaman, Ronald

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AU - Paul-Brutus, Rachelle

AU - Segers, Stephanie

AU - Slavkovich, Vesna

AU - Islam, Tariqul

AU - Levy, Diane

AU - Mey, Jacob L.

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AB - The authors conducted a cross-sectional study to assess the relation between arsenic exposure fromdrinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95%confidence interval: 1.01, 1.03) and 1.04 (95%confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher bodymass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.

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