Assessment of the anti-microbial agent C31G as a spermicide: Comparison with nonoxynol-9

Kathleen A. Thompson, Daniel Malamud, Storey T. Bayard

Research output: Contribution to journalArticle

Abstract

The broad-spectrum anti-microbial agent, C31G, containing an equimolar mixture of n-dodecyl-dimethylamine-N-oxide (C12-N-O) and N (n-dodecyl), N- dimethyl-glycine (C12-betaine), was tested for spermicidal activity in comparison with the currently used spermicide, nonoxynol-9 (N-9). The rate of sperm cell permeabilization by the spermicides, as assayed with the fluorescent probe, TO-PRO-1, increased as the cube of the C31G concentration, while the rate increase was linear with N-9 concentration. At 0.04%, the rate of sperm cell permeabilization with both spermicides is at the limit of rapid measurement. C31G diffuses through cervical mucus at a more rapid rate than does N-9. C31G has long been known to aid wound healing and reduce inflammation, whereas N-9 has been reported to induce vaginal irritation. C31G would, thus, seem to have the spermicidal efficacy, the broad range of anti-microbial activity, and the lack of inflammatory activity that is sought in the ideal vaginal spermicide.

Original languageEnglish (US)
Pages (from-to)313-318
Number of pages6
JournalContraception
Volume53
Issue number5
DOIs
StatePublished - May 1996

Fingerprint

Nonoxynol
Anti-Infective Agents
Spermatozoa
Spermatocidal Agents
Cervix Mucus
Betaine
Fluorescent Dyes
Wound Healing
Oxides
C 31G
Inflammation

Keywords

  • anti-microbial
  • C31G efficacy
  • cervical mucus
  • nonoxynol-9
  • sperm permeabilization
  • TO-PRO-1 cell lysis probe

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Assessment of the anti-microbial agent C31G as a spermicide : Comparison with nonoxynol-9. / Thompson, Kathleen A.; Malamud, Daniel; Bayard, Storey T.

In: Contraception, Vol. 53, No. 5, 05.1996, p. 313-318.

Research output: Contribution to journalArticle

Thompson, Kathleen A. ; Malamud, Daniel ; Bayard, Storey T. / Assessment of the anti-microbial agent C31G as a spermicide : Comparison with nonoxynol-9. In: Contraception. 1996 ; Vol. 53, No. 5. pp. 313-318.
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