Assessing antiretroviral adherence via electronic drug monitoring and self-report: An examination of key methodological issues

Cynthia R. Pearson, Jane M. Simoni, Peter Hoff, Ann E. Kurth, Diane P. Martin

Research output: Contribution to journalArticle

Abstract

We explored methodological issues related to antiretroviral adherence assessment, using 6 months of data collected in a completed intervention trial involving 136 low-income HIV-positive outpatients in the Bronx, NY. Findings suggest that operationalizing adherence as a continuous (versus dichotomous) variable and averaging adherence estimates over multiple assessment points (versus using only one) explains greater variance in HIV-1 RNA viral load (VL). Self-reported estimates provided during a phone interview accounted for similar variance in VL as EDM estimates (R 2 = .17 phone versus .18 EDM). Self-reported adherence was not associated with a standard social desirability measure, and no difference in the accuracy of self-report adherence was observed for assessment periods of 1-3 days. Self-reported poor adherence was more closely associated with EDM adherence estimates than self-reported moderate and high adherence. On average across assessment points, fewer than 4% of participants who reported taking a dose of an incorrect amount of medication.

Original languageEnglish (US)
Pages (from-to)161-173
Number of pages13
JournalAIDS and Behavior
Volume11
Issue number2
DOIs
StatePublished - Mar 2007

Fingerprint

Drug Monitoring
Viral Load
Self Report
Social Desirability
HIV-1
Outpatients
HIV
RNA
Interviews

Keywords

  • Antiretroviral adherence assessment
  • Electronic drug monitoring
  • HAART
  • HIV/AIDS
  • MEMS
  • Self-report

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

Cite this

Assessing antiretroviral adherence via electronic drug monitoring and self-report : An examination of key methodological issues. / Pearson, Cynthia R.; Simoni, Jane M.; Hoff, Peter; Kurth, Ann E.; Martin, Diane P.

In: AIDS and Behavior, Vol. 11, No. 2, 03.2007, p. 161-173.

Research output: Contribution to journalArticle

Pearson, Cynthia R. ; Simoni, Jane M. ; Hoff, Peter ; Kurth, Ann E. ; Martin, Diane P. / Assessing antiretroviral adherence via electronic drug monitoring and self-report : An examination of key methodological issues. In: AIDS and Behavior. 2007 ; Vol. 11, No. 2. pp. 161-173.
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