Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics

Charlotte L. Sutherell, Sam Thompson, Richard T W Scott, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

We describe the design and synthesis of a non-peptidic β-strand mimetic composed of alternating aryl and imidazolidin-2-one rings that can be adapted to display diverse side-chains. Solid- and solution-phase data together with calculations suggest that the desired conformation for side-chain mimicry is readily accessible and well-populated.

Original languageEnglish (US)
Pages (from-to)9834-9836
Number of pages3
JournalChemical Communications
Volume48
Issue number79
DOIs
StatePublished - Oct 11 2012

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ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. / Sutherell, Charlotte L.; Thompson, Sam; Scott, Richard T W; Hamilton, Andrew.

In: Chemical Communications, Vol. 48, No. 79, 11.10.2012, p. 9834-9836.

Research output: Contribution to journalArticle

Sutherell, Charlotte L. ; Thompson, Sam ; Scott, Richard T W ; Hamilton, Andrew. / Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. In: Chemical Communications. 2012 ; Vol. 48, No. 79. pp. 9834-9836.
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