Artificial receptors for biologically active molecules

Andrew D. Hamilton, Nalin Pant, Alexander Muehldorf

Research output: Contribution to journalArticle

Abstract

Artificial receptors for two key classes of bio- logical molecules, nucleotides and peptides, have been prepared. The nucleotide receptors mimick nucleotide binding enzymes by employing a multi-point binding strategy within a flexible cavity. Complementary hydrogen bonding and hydrophobic groups have been linked within a macrocyclic ring to provide a series of thymine receptors. Binding has been studied by NMR and X-ray crystallographic methods which show that both components interact with the bound substrate. A series of potential peptide receptors based on the antibiotic, vancomycin, have also been prepared and their structural and functional similarities to the natural product have been studied.

Original languageEnglish (US)
Pages (from-to)533-538
Number of pages6
JournalPure and Applied Chemistry
Volume60
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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