Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh

Yu Chen, Fen Wu, Joseph H. Graziano, Faruque Parvez, Mengling Liu, Rina Rani Paul, Ishrat Shaheen, Golam Sarwar, Alauddin Ahmed, Tariqul Islam, Vesna Slavkovich, Tatjana Rundek, Ryan T. Demmer, Moise Desvarieux, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

We conducted a cross-sectional study to evaluate the interrelationships between past arsenic exposure, biomarkers specific for susceptibility to arsenic exposure, and carotid intima-media thickness (cIMT) in 959 subjects from the Health Effects of Arsenic Longitudinal Study in Bangladesh. We measured cIMT levels on average 7.2 years after baseline during 2010-2011. Arsenic exposure was measured in well water at baseline and in urine samples collected at baseline and during follow-up. Every 1-standard-deviation increase in urinary arsenic (357.9 μg/g creatinine) and well-water arsenic (102.0 μg/L) concentration was related to a 11.7-μm (95% confidence interval (CI): 1.8, 21.6) and 5.1-μm (95% CI:-0.2, 10.3) increase in cIMT, respectively. For every 10% increase in monomethylarsonic acid (MMA) percentage, there was an increase of 12.1 μm (95% CI: 0.4, 23.8) in cIMT. Among participants with a higher urinary MMA percentage, a higher ratio of urinary MMA to inorganic arsenic, and a lower ratio of dimethylarsinic acid to MMA, the association between well-water arsenic and cIMT was stronger. The findings indicate an effect of past long-term arsenic exposure on cIMT, which may be potentiated by suboptimal or incomplete arsenic methylation capacity. Future prospective studies are needed to confirm the association between arsenic methylation capacity and atherosclerosis-related outcomes.

Original languageEnglish (US)
Pages (from-to)372-381
Number of pages10
JournalAmerican Journal of Epidemiology
Volume178
Issue number3
DOIs
StatePublished - Aug 1 2013

Fingerprint

Carotid Intima-Media Thickness
Bangladesh
Arsenic
Drinking Water
Methylation
Confidence Intervals
Water
Cacodylic Acid
Longitudinal Studies
Creatinine
Atherosclerosis
Cross-Sectional Studies
Biomarkers
Urine
Prospective Studies

Keywords

  • arsenic
  • Bangladesh
  • cardiovascular diseases
  • carotid intima-media thickness
  • drinking water

ASJC Scopus subject areas

  • Epidemiology

Cite this

Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh. / Chen, Yu; Wu, Fen; Graziano, Joseph H.; Parvez, Faruque; Liu, Mengling; Paul, Rina Rani; Shaheen, Ishrat; Sarwar, Golam; Ahmed, Alauddin; Islam, Tariqul; Slavkovich, Vesna; Rundek, Tatjana; Demmer, Ryan T.; Desvarieux, Moise; Ahsan, Habibul.

In: American Journal of Epidemiology, Vol. 178, No. 3, 01.08.2013, p. 372-381.

Research output: Contribution to journalArticle

Chen, Y, Wu, F, Graziano, JH, Parvez, F, Liu, M, Paul, RR, Shaheen, I, Sarwar, G, Ahmed, A, Islam, T, Slavkovich, V, Rundek, T, Demmer, RT, Desvarieux, M & Ahsan, H 2013, 'Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh', American Journal of Epidemiology, vol. 178, no. 3, pp. 372-381. https://doi.org/10.1093/aje/kwt001
Chen, Yu ; Wu, Fen ; Graziano, Joseph H. ; Parvez, Faruque ; Liu, Mengling ; Paul, Rina Rani ; Shaheen, Ishrat ; Sarwar, Golam ; Ahmed, Alauddin ; Islam, Tariqul ; Slavkovich, Vesna ; Rundek, Tatjana ; Demmer, Ryan T. ; Desvarieux, Moise ; Ahsan, Habibul. / Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh. In: American Journal of Epidemiology. 2013 ; Vol. 178, No. 3. pp. 372-381.
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AU - Paul, Rina Rani

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AU - Ahmed, Alauddin

AU - Islam, Tariqul

AU - Slavkovich, Vesna

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