Arsenic exposure from drinking water and QT-interval prolongation: Results from the health effects of arsenic longitudinal study

Yu Chen, Fen Wu, Faruque Parvez, Alauddin Ahmed, Mahbub Eunus, Tyler R. Mcclintock, Tazul Islam Patwary, Tariqul Islam, Anajan Kumar Ghosal, Shahidul Islam, Rabiul Hasan, Diane Levy, Golam Sarwar, Vesna Slavkovich, Alexander van Geen, Joseph H. Graziano, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

Background: Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain. Objective: We evaluated the association between a history of arsenic exposure from drinking water and the prolongation of heart rate-corrected QT (QTc), PR, and QRS intervals. Method: We conducted a study of 1,715 participants enrolled at baseline from the Health Effects of Arsenic Longitudinal Study. We assessed the relationship of arsenic exposure in well water and urine samples at baseline with parameters of electrocardiogram (ECG) performed during 2005-2010, 5.9 years on average since baseline. Results: The adjusted odds ratio (OR) for QTc prolongation, defined as a QTc ≥ 450 msec in men and ≥ 460 msec in women, was 1.17 (95% CI: 1.01, 1.35) for a 1-SD increase in well-water arsenic (108.7 μg/L). The positive association appeared to be limited to women, with adjusted ORs of 1.24 (95% CI: 1.05, 1.47) and 1.24 (95% CI: 1.01, 1.53) for a 1-SD increase in baseline well-water and urinary arsenic, respectively, compared with 0.99 (95% CI: 0.73, 1.33) and 0.86 (95% CI: 0.49, 1.51) in men. There were no apparent associations of baseline well-water arsenic or urinary arsenic with PR or QRS prolongation in women or men. Conclusions: Long-term arsenic exposure from drinking water (average 95 μg/L; range, 0.1-790 μg/L) was associated with subsequent QT-interval prolongation in women. Future longitudinal studies with repeated ECG measurements would be valuable in assessing the influence of changes in exposure.

Original languageEnglish (US)
Pages (from-to)427-432
Number of pages6
JournalEnvironmental Health Perspectives
Volume121
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Arsenic
Drinking Water
Longitudinal Studies
Health
Water
Electrocardiography
Heart Diseases
Heart Rate
Odds Ratio
Urine

Keywords

  • Arsenic
  • Bangladesh
  • Cardiovascular disease
  • Electrocardiogram
  • Environmental exposure
  • Heart rate-corrected QT interval

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health

Cite this

Arsenic exposure from drinking water and QT-interval prolongation : Results from the health effects of arsenic longitudinal study. / Chen, Yu; Wu, Fen; Parvez, Faruque; Ahmed, Alauddin; Eunus, Mahbub; Mcclintock, Tyler R.; Patwary, Tazul Islam; Islam, Tariqul; Ghosal, Anajan Kumar; Islam, Shahidul; Hasan, Rabiul; Levy, Diane; Sarwar, Golam; Slavkovich, Vesna; van Geen, Alexander; Graziano, Joseph H.; Ahsan, Habibul.

In: Environmental Health Perspectives, Vol. 121, No. 4, 04.2013, p. 427-432.

Research output: Contribution to journalArticle

Chen, Y, Wu, F, Parvez, F, Ahmed, A, Eunus, M, Mcclintock, TR, Patwary, TI, Islam, T, Ghosal, AK, Islam, S, Hasan, R, Levy, D, Sarwar, G, Slavkovich, V, van Geen, A, Graziano, JH & Ahsan, H 2013, 'Arsenic exposure from drinking water and QT-interval prolongation: Results from the health effects of arsenic longitudinal study', Environmental Health Perspectives, vol. 121, no. 4, pp. 427-432. https://doi.org/10.1289/ehp.1205197
Chen, Yu ; Wu, Fen ; Parvez, Faruque ; Ahmed, Alauddin ; Eunus, Mahbub ; Mcclintock, Tyler R. ; Patwary, Tazul Islam ; Islam, Tariqul ; Ghosal, Anajan Kumar ; Islam, Shahidul ; Hasan, Rabiul ; Levy, Diane ; Sarwar, Golam ; Slavkovich, Vesna ; van Geen, Alexander ; Graziano, Joseph H. ; Ahsan, Habibul. / Arsenic exposure from drinking water and QT-interval prolongation : Results from the health effects of arsenic longitudinal study. In: Environmental Health Perspectives. 2013 ; Vol. 121, No. 4. pp. 427-432.
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abstract = "Background: Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain. Objective: We evaluated the association between a history of arsenic exposure from drinking water and the prolongation of heart rate-corrected QT (QTc), PR, and QRS intervals. Method: We conducted a study of 1,715 participants enrolled at baseline from the Health Effects of Arsenic Longitudinal Study. We assessed the relationship of arsenic exposure in well water and urine samples at baseline with parameters of electrocardiogram (ECG) performed during 2005-2010, 5.9 years on average since baseline. Results: The adjusted odds ratio (OR) for QTc prolongation, defined as a QTc ≥ 450 msec in men and ≥ 460 msec in women, was 1.17 (95{\%} CI: 1.01, 1.35) for a 1-SD increase in well-water arsenic (108.7 μg/L). The positive association appeared to be limited to women, with adjusted ORs of 1.24 (95{\%} CI: 1.05, 1.47) and 1.24 (95{\%} CI: 1.01, 1.53) for a 1-SD increase in baseline well-water and urinary arsenic, respectively, compared with 0.99 (95{\%} CI: 0.73, 1.33) and 0.86 (95{\%} CI: 0.49, 1.51) in men. There were no apparent associations of baseline well-water arsenic or urinary arsenic with PR or QRS prolongation in women or men. Conclusions: Long-term arsenic exposure from drinking water (average 95 μg/L; range, 0.1-790 μg/L) was associated with subsequent QT-interval prolongation in women. Future longitudinal studies with repeated ECG measurements would be valuable in assessing the influence of changes in exposure.",
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T2 - Results from the health effects of arsenic longitudinal study

AU - Chen, Yu

AU - Wu, Fen

AU - Parvez, Faruque

AU - Ahmed, Alauddin

AU - Eunus, Mahbub

AU - Mcclintock, Tyler R.

AU - Patwary, Tazul Islam

AU - Islam, Tariqul

AU - Ghosal, Anajan Kumar

AU - Islam, Shahidul

AU - Hasan, Rabiul

AU - Levy, Diane

AU - Sarwar, Golam

AU - Slavkovich, Vesna

AU - van Geen, Alexander

AU - Graziano, Joseph H.

AU - Ahsan, Habibul

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N2 - Background: Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain. Objective: We evaluated the association between a history of arsenic exposure from drinking water and the prolongation of heart rate-corrected QT (QTc), PR, and QRS intervals. Method: We conducted a study of 1,715 participants enrolled at baseline from the Health Effects of Arsenic Longitudinal Study. We assessed the relationship of arsenic exposure in well water and urine samples at baseline with parameters of electrocardiogram (ECG) performed during 2005-2010, 5.9 years on average since baseline. Results: The adjusted odds ratio (OR) for QTc prolongation, defined as a QTc ≥ 450 msec in men and ≥ 460 msec in women, was 1.17 (95% CI: 1.01, 1.35) for a 1-SD increase in well-water arsenic (108.7 μg/L). The positive association appeared to be limited to women, with adjusted ORs of 1.24 (95% CI: 1.05, 1.47) and 1.24 (95% CI: 1.01, 1.53) for a 1-SD increase in baseline well-water and urinary arsenic, respectively, compared with 0.99 (95% CI: 0.73, 1.33) and 0.86 (95% CI: 0.49, 1.51) in men. There were no apparent associations of baseline well-water arsenic or urinary arsenic with PR or QRS prolongation in women or men. Conclusions: Long-term arsenic exposure from drinking water (average 95 μg/L; range, 0.1-790 μg/L) was associated with subsequent QT-interval prolongation in women. Future longitudinal studies with repeated ECG measurements would be valuable in assessing the influence of changes in exposure.

AB - Background: Arsenic exposure from drinking water has been associated with heart disease; however, underlying mechanisms are uncertain. Objective: We evaluated the association between a history of arsenic exposure from drinking water and the prolongation of heart rate-corrected QT (QTc), PR, and QRS intervals. Method: We conducted a study of 1,715 participants enrolled at baseline from the Health Effects of Arsenic Longitudinal Study. We assessed the relationship of arsenic exposure in well water and urine samples at baseline with parameters of electrocardiogram (ECG) performed during 2005-2010, 5.9 years on average since baseline. Results: The adjusted odds ratio (OR) for QTc prolongation, defined as a QTc ≥ 450 msec in men and ≥ 460 msec in women, was 1.17 (95% CI: 1.01, 1.35) for a 1-SD increase in well-water arsenic (108.7 μg/L). The positive association appeared to be limited to women, with adjusted ORs of 1.24 (95% CI: 1.05, 1.47) and 1.24 (95% CI: 1.01, 1.53) for a 1-SD increase in baseline well-water and urinary arsenic, respectively, compared with 0.99 (95% CI: 0.73, 1.33) and 0.86 (95% CI: 0.49, 1.51) in men. There were no apparent associations of baseline well-water arsenic or urinary arsenic with PR or QRS prolongation in women or men. Conclusions: Long-term arsenic exposure from drinking water (average 95 μg/L; range, 0.1-790 μg/L) was associated with subsequent QT-interval prolongation in women. Future longitudinal studies with repeated ECG measurements would be valuable in assessing the influence of changes in exposure.

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KW - Bangladesh

KW - Cardiovascular disease

KW - Electrocardiogram

KW - Environmental exposure

KW - Heart rate-corrected QT interval

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