Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh

A population-based study

Gene R. Pesola, Faruque Parvez, Yu Chen, Alauddin Ahmed, Rabiul Hasan, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

Bangladesh has high well water arsenic exposure. Chronic arsenic ingestion may result in diseases that manifest as dyspnoea, although information is sparse. Baseline values were obtained from an arsenic study. Trained physicians ascertained data on dyspnoea among 11,746 subjects. Data were collected on demographic factors, including smoking, blood pressure and arsenic exposure. Logistic regression models estimated odds ratios and confidence intervals for the association between arsenic exposure and dyspnoea. The adjusted odds of having dyspnoea was 1.32-fold (95% CI 1.15-1.52) greater in those exposed to high well water arsenic concentrations (≥50 μg·L -1) compared with low-arsenic-exposed nonsmokers (p<0.01). A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea. In nonsmokers, the adjusted odds of having dyspnoea were 1.36, 1.96, 2.34 and 1.80-fold greater for arsenic concentrations of 7-38, 39-90, 91- 178 and 179-864 μg·L -1, respectively, compared with the reference arsenic concentration of <7 μg·L -1 (p<0.01; Chi-squared test for trend). Arsenic exposure through well water is associated with dyspnoea, independently of smoking status. This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary. Copyright

Original languageEnglish (US)
Pages (from-to)1076-1083
Number of pages8
JournalEuropean Respiratory Journal
Volume39
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Bangladesh
Arsenic
Drinking Water
Dyspnea
Population
Water
Smoking
Logistic Models
Eating
Odds Ratio
Demography

Keywords

  • Arsenicosis
  • Dyspnoea dose-response
  • Environmental dyspnoea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh : A population-based study. / Pesola, Gene R.; Parvez, Faruque; Chen, Yu; Ahmed, Alauddin; Hasan, Rabiul; Ahsan, Habibul.

In: European Respiratory Journal, Vol. 39, No. 5, 01.05.2012, p. 1076-1083.

Research output: Contribution to journalArticle

Pesola, Gene R. ; Parvez, Faruque ; Chen, Yu ; Ahmed, Alauddin ; Hasan, Rabiul ; Ahsan, Habibul. / Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh : A population-based study. In: European Respiratory Journal. 2012 ; Vol. 39, No. 5. pp. 1076-1083.
@article{ed9323366dc04bddb1b870ec447e3754,
title = "Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: A population-based study",
abstract = "Bangladesh has high well water arsenic exposure. Chronic arsenic ingestion may result in diseases that manifest as dyspnoea, although information is sparse. Baseline values were obtained from an arsenic study. Trained physicians ascertained data on dyspnoea among 11,746 subjects. Data were collected on demographic factors, including smoking, blood pressure and arsenic exposure. Logistic regression models estimated odds ratios and confidence intervals for the association between arsenic exposure and dyspnoea. The adjusted odds of having dyspnoea was 1.32-fold (95{\%} CI 1.15-1.52) greater in those exposed to high well water arsenic concentrations (≥50 μg·L -1) compared with low-arsenic-exposed nonsmokers (p<0.01). A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea. In nonsmokers, the adjusted odds of having dyspnoea were 1.36, 1.96, 2.34 and 1.80-fold greater for arsenic concentrations of 7-38, 39-90, 91- 178 and 179-864 μg·L -1, respectively, compared with the reference arsenic concentration of <7 μg·L -1 (p<0.01; Chi-squared test for trend). Arsenic exposure through well water is associated with dyspnoea, independently of smoking status. This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary. Copyright",
keywords = "Arsenicosis, Dyspnoea dose-response, Environmental dyspnoea",
author = "Pesola, {Gene R.} and Faruque Parvez and Yu Chen and Alauddin Ahmed and Rabiul Hasan and Habibul Ahsan",
year = "2012",
month = "5",
day = "1",
doi = "10.1183/09031936.00042611",
language = "English (US)",
volume = "39",
pages = "1076--1083",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

TY - JOUR

T1 - Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh

T2 - A population-based study

AU - Pesola, Gene R.

AU - Parvez, Faruque

AU - Chen, Yu

AU - Ahmed, Alauddin

AU - Hasan, Rabiul

AU - Ahsan, Habibul

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Bangladesh has high well water arsenic exposure. Chronic arsenic ingestion may result in diseases that manifest as dyspnoea, although information is sparse. Baseline values were obtained from an arsenic study. Trained physicians ascertained data on dyspnoea among 11,746 subjects. Data were collected on demographic factors, including smoking, blood pressure and arsenic exposure. Logistic regression models estimated odds ratios and confidence intervals for the association between arsenic exposure and dyspnoea. The adjusted odds of having dyspnoea was 1.32-fold (95% CI 1.15-1.52) greater in those exposed to high well water arsenic concentrations (≥50 μg·L -1) compared with low-arsenic-exposed nonsmokers (p<0.01). A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea. In nonsmokers, the adjusted odds of having dyspnoea were 1.36, 1.96, 2.34 and 1.80-fold greater for arsenic concentrations of 7-38, 39-90, 91- 178 and 179-864 μg·L -1, respectively, compared with the reference arsenic concentration of <7 μg·L -1 (p<0.01; Chi-squared test for trend). Arsenic exposure through well water is associated with dyspnoea, independently of smoking status. This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary. Copyright

AB - Bangladesh has high well water arsenic exposure. Chronic arsenic ingestion may result in diseases that manifest as dyspnoea, although information is sparse. Baseline values were obtained from an arsenic study. Trained physicians ascertained data on dyspnoea among 11,746 subjects. Data were collected on demographic factors, including smoking, blood pressure and arsenic exposure. Logistic regression models estimated odds ratios and confidence intervals for the association between arsenic exposure and dyspnoea. The adjusted odds of having dyspnoea was 1.32-fold (95% CI 1.15-1.52) greater in those exposed to high well water arsenic concentrations (≥50 μg·L -1) compared with low-arsenic-exposed nonsmokers (p<0.01). A significant dose-response relationship was found for arsenic (as well as smoking) in relation to dyspnoea. In nonsmokers, the adjusted odds of having dyspnoea were 1.36, 1.96, 2.34 and 1.80-fold greater for arsenic concentrations of 7-38, 39-90, 91- 178 and 179-864 μg·L -1, respectively, compared with the reference arsenic concentration of <7 μg·L -1 (p<0.01; Chi-squared test for trend). Arsenic exposure through well water is associated with dyspnoea, independently of smoking status. This study suggests that mandated well water testing for arsenic with reduction in exposure may significantly reduce diseases that manifest as dyspnoea, usually cardiac or pulmonary. Copyright

KW - Arsenicosis

KW - Dyspnoea dose-response

KW - Environmental dyspnoea

UR - http://www.scopus.com/inward/record.url?scp=84860429936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860429936&partnerID=8YFLogxK

U2 - 10.1183/09031936.00042611

DO - 10.1183/09031936.00042611

M3 - Article

VL - 39

SP - 1076

EP - 1083

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

ER -