Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces

Paulo Coelho, Gabriela Giro, Hellen S. Teixeira, Charles Marin, Lukasz Witek, Van P. Thompson, Nick Tovar, Nelson R F A Silva

Research output: Contribution to journalArticle

Abstract

This study investigated the effect of an Argon-based atmospheric pressure plasma (APP) surface treatment operated chairside at atmospheric pressure conditions applied immediately prior to dental implant placement in a canine model. Surfaces investigated comprised: rough titanium surface (Ti) and rough titanium surface + Argon-based APP (Ti-Plasma). Surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and chemistry by X-ray photoelectron spectroscopy (XPS). Six adult beagles dogs received two plateau-root form implants (n = 1 each surface) in each radii, providing implants that remained 1 and 3 weeks in vivo. Histometric parameters assessed were bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed by Kruskall-Wallis (95% level of significance) and Dunn's post-hoc test. The XPS analysis showed peaks of Ti, C, and O for the Ti and Ti- Plasma surfaces. Both surfaces presented carbon primarily as hydrocarbon (C - C, C - H) with lower levels of oxidized carbon forms. The Ti-Plasma presented large increase in the Ti (+11%) and O (+16%) elements for the Ti- Plasma group along with a decrease of 23% in surface-adsorbed C content. At 1 week no difference was found in histometric parameters between groups. At 3 weeks significantly higher BIC (>300%) and mean BAFO (>30%) were observed for Ti-Plasma treated surfaces. From a morphologic standpoint, improved interaction between connective tissue was observed at 1 week, likely leading to more uniform and higher bone formation at 3 weeks for the Ti-Plasma treated implants was observed.

Original languageEnglish (US)
Pages (from-to)1901-1906
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume100 A
Issue number7
DOIs
StatePublished - Jul 2012

Fingerprint

Argon
Titanium
Atmospheric pressure
Bone
Plasmas
Carbon
X ray photoelectron spectroscopy
Dental prostheses
Hydrocarbons
Interfacial energy
Surface treatment
Statistical methods
Tissue

Keywords

  • atmospheric pressure plasma plasma
  • endosseous implant
  • osseointegration
  • surface treatment

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys

Cite this

Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces. / Coelho, Paulo; Giro, Gabriela; Teixeira, Hellen S.; Marin, Charles; Witek, Lukasz; Thompson, Van P.; Tovar, Nick; Silva, Nelson R F A.

In: Journal of Biomedical Materials Research - Part A, Vol. 100 A, No. 7, 07.2012, p. 1901-1906.

Research output: Contribution to journalArticle

Coelho, Paulo ; Giro, Gabriela ; Teixeira, Hellen S. ; Marin, Charles ; Witek, Lukasz ; Thompson, Van P. ; Tovar, Nick ; Silva, Nelson R F A. / Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces. In: Journal of Biomedical Materials Research - Part A. 2012 ; Vol. 100 A, No. 7. pp. 1901-1906.
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abstract = "This study investigated the effect of an Argon-based atmospheric pressure plasma (APP) surface treatment operated chairside at atmospheric pressure conditions applied immediately prior to dental implant placement in a canine model. Surfaces investigated comprised: rough titanium surface (Ti) and rough titanium surface + Argon-based APP (Ti-Plasma). Surface energy was characterized by the Owens-Wendt-Rabel-Kaelble method and chemistry by X-ray photoelectron spectroscopy (XPS). Six adult beagles dogs received two plateau-root form implants (n = 1 each surface) in each radii, providing implants that remained 1 and 3 weeks in vivo. Histometric parameters assessed were bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO). Statistical analysis was performed by Kruskall-Wallis (95{\%} level of significance) and Dunn's post-hoc test. The XPS analysis showed peaks of Ti, C, and O for the Ti and Ti- Plasma surfaces. Both surfaces presented carbon primarily as hydrocarbon (C - C, C - H) with lower levels of oxidized carbon forms. The Ti-Plasma presented large increase in the Ti (+11{\%}) and O (+16{\%}) elements for the Ti- Plasma group along with a decrease of 23{\%} in surface-adsorbed C content. At 1 week no difference was found in histometric parameters between groups. At 3 weeks significantly higher BIC (>300{\%}) and mean BAFO (>30{\%}) were observed for Ti-Plasma treated surfaces. From a morphologic standpoint, improved interaction between connective tissue was observed at 1 week, likely leading to more uniform and higher bone formation at 3 weeks for the Ti-Plasma treated implants was observed.",
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