Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate

Timothy J. Petros, Ronald S. Bultje, M. Elizabeth Ross, Gordon Fishell, Stewart A. Anderson

Research output: Contribution to journalArticle

Abstract

Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area of study in neuroscience. Most studies investigating this topic focus on the diversity of neural progenitors within spatial and temporal domains along the lateral ventricles. Often overlooked is whether the location of neurogenesis within a fate-restricted domain is associated with, or instructive for, distinct neuronal fates. Here, we use in vivo fate mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon. Somatostatin-expressing interneurons arise mainly from apical divisions along the ventricular surface, whereas parvalbumin-expressing interneurons originate predominantly from basal divisions in the subventricular zone. As manipulations that shift neurogenic location alter interneuron subclass fate, these results add an additional dimension to the spatial-temporal determinants of neuronal fate determination. Petros et al. reveal that the location of neurogenic divisions is a critical mechanism for determining interneuron fate. Somatostatin-expressing interneurons are derived predominantly from apical progenitors within the ventricular zone, whereas parvalbumin-expressing interneurons are generated from basal progenitor divisions in the subventricular zone.

Original languageEnglish (US)
Pages (from-to)1090-1095
Number of pages6
JournalCell Reports
Volume13
Issue number6
DOIs
StatePublished - Nov 10 2015

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Neurogenesis
Interneurons
Parvalbumins
Somatostatin
Lateral Ventricles
Telencephalon
Neurosciences

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate. / Petros, Timothy J.; Bultje, Ronald S.; Ross, M. Elizabeth; Fishell, Gordon; Anderson, Stewart A.

In: Cell Reports, Vol. 13, No. 6, 10.11.2015, p. 1090-1095.

Research output: Contribution to journalArticle

Petros, Timothy J. ; Bultje, Ronald S. ; Ross, M. Elizabeth ; Fishell, Gordon ; Anderson, Stewart A. / Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate. In: Cell Reports. 2015 ; Vol. 13, No. 6. pp. 1090-1095.
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