Antiviral activities in human saliva.

Daniel Malamud, W. R. Abrams, C. A. Barber, D. Weissman, M. Rehtanz, E. Golub

Research output: Contribution to journalArticle

Abstract

In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)34-37
Number of pages4
JournalAdvances in dental research
Volume23
Issue number1
DOIs
StatePublished - Apr 2011

Fingerprint

Saliva
Human Activities
Antiviral Agents
Mouth
HIV-1
Bacteria
Proteins
Agglutinins
Human Influenza
HIV Infections
Tooth
Viruses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Malamud, D., Abrams, W. R., Barber, C. A., Weissman, D., Rehtanz, M., & Golub, E. (2011). Antiviral activities in human saliva. Advances in dental research, 23(1), 34-37. https://doi.org/10.1177/0022034511399282

Antiviral activities in human saliva. / Malamud, Daniel; Abrams, W. R.; Barber, C. A.; Weissman, D.; Rehtanz, M.; Golub, E.

In: Advances in dental research, Vol. 23, No. 1, 04.2011, p. 34-37.

Research output: Contribution to journalArticle

Malamud, D, Abrams, WR, Barber, CA, Weissman, D, Rehtanz, M & Golub, E 2011, 'Antiviral activities in human saliva.', Advances in dental research, vol. 23, no. 1, pp. 34-37. https://doi.org/10.1177/0022034511399282
Malamud D, Abrams WR, Barber CA, Weissman D, Rehtanz M, Golub E. Antiviral activities in human saliva. Advances in dental research. 2011 Apr;23(1):34-37. https://doi.org/10.1177/0022034511399282
Malamud, Daniel ; Abrams, W. R. ; Barber, C. A. ; Weissman, D. ; Rehtanz, M. ; Golub, E. / Antiviral activities in human saliva. In: Advances in dental research. 2011 ; Vol. 23, No. 1. pp. 34-37.
@article{a20acde356d640699594bdac03eae7f8,
title = "Antiviral activities in human saliva.",
abstract = "In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.",
author = "Daniel Malamud and Abrams, {W. R.} and Barber, {C. A.} and D. Weissman and M. Rehtanz and E. Golub",
year = "2011",
month = "4",
doi = "10.1177/0022034511399282",
language = "English (US)",
volume = "23",
pages = "34--37",
journal = "Advances in dental research",
issn = "0895-9374",
publisher = "International Association for Dental Research",
number = "1",

}

TY - JOUR

T1 - Antiviral activities in human saliva.

AU - Malamud, Daniel

AU - Abrams, W. R.

AU - Barber, C. A.

AU - Weissman, D.

AU - Rehtanz, M.

AU - Golub, E.

PY - 2011/4

Y1 - 2011/4

N2 - In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.

AB - In this review, the authors survey the large number of antibacterial and antiviral proteins present in human saliva. Of interest, most of these antibacterial proteins display antiviral activity, typically against specific viral pathogens. The review focuses on one protein that interacts with both bacteria and viruses-gp340, originally referred to as salivary agglutinin. In the oral cavity, soluble gp340 binds to and aggregates a variety of bacteria, and this is thought to increase bacterial clearance from the mouth. However, when bound to the tooth surface, gp340 promotes bacterial adherence. In the oral cavity, most gp340 is found soluble in saliva and can function as a specific inhibitor of infectivity of HIV-1 and influenza A. In contrast, in the female reproductive track, most gp340 is bound to the cell surface, where it can promote HIV-1 infection.

UR - http://www.scopus.com/inward/record.url?scp=79954601585&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79954601585&partnerID=8YFLogxK

U2 - 10.1177/0022034511399282

DO - 10.1177/0022034511399282

M3 - Article

VL - 23

SP - 34

EP - 37

JO - Advances in dental research

JF - Advances in dental research

SN - 0895-9374

IS - 1

ER -