Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: Comparison of self-report and electronic monitoring

J. H. Arnsten, P. A. Demas, H. Farzadegan, R. W. Grant, Marc Gourevitch, C. J. Chang, D. Buono, H. Eckholdt, A. A. Howard, E. E. Schoenbaum

Research output: Contribution to journalArticle

Abstract

To compare electronically monitored (MEMS) with self-reported adherence in drug users, including the impact of adherence on HIV load, we conducted a 6-month observational study of 67 antiretroviral-experienced current and former drug users. Adherence (percentage of doses taken as prescribed) was calculated for both the day and the week preceding each of 6 research visits. Mean self-reported 1-day adherence was 79% (median, 86%), and mean self-reported 1-week adherence was 78% (median, 85%). Mean MEMS 1-day adherence was 57% (median, 52%), and mean MEMS 1-week adherence was 53% (median, 49%). One-day and 1-week estimates were highly correlated (r>.8 for both measures). Both self-reported and MEMS adherence were correlated with concurrent HIV load (r=.43-.60), but the likelihood of achieving virologic suppression was greater if MEMS adherence was high than if self-reported adherence was high. We conclude that self-reported adherence is higher than MEMS adherence, but a strong relationship exists between both measures and virus load. However, electronic monitoring is more sensitive than self-report for the detection of nonadherence and should be used in adherence intervention studies.

Original languageEnglish (US)
Pages (from-to)1417-1423
Number of pages7
JournalClinical Infectious Diseases
Volume33
Issue number8
DOIs
StatePublished - Oct 15 2001

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Micro-Electrical-Mechanical Systems
Drug Users
Self Report
HIV
Therapeutics
Observational Studies
Viruses
Research

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Antiretroviral therapy adherence and viral suppression in HIV-infected drug users : Comparison of self-report and electronic monitoring. / Arnsten, J. H.; Demas, P. A.; Farzadegan, H.; Grant, R. W.; Gourevitch, Marc; Chang, C. J.; Buono, D.; Eckholdt, H.; Howard, A. A.; Schoenbaum, E. E.

In: Clinical Infectious Diseases, Vol. 33, No. 8, 15.10.2001, p. 1417-1423.

Research output: Contribution to journalArticle

Arnsten, JH, Demas, PA, Farzadegan, H, Grant, RW, Gourevitch, M, Chang, CJ, Buono, D, Eckholdt, H, Howard, AA & Schoenbaum, EE 2001, 'Antiretroviral therapy adherence and viral suppression in HIV-infected drug users: Comparison of self-report and electronic monitoring', Clinical Infectious Diseases, vol. 33, no. 8, pp. 1417-1423. https://doi.org/10.1086/323201
Arnsten, J. H. ; Demas, P. A. ; Farzadegan, H. ; Grant, R. W. ; Gourevitch, Marc ; Chang, C. J. ; Buono, D. ; Eckholdt, H. ; Howard, A. A. ; Schoenbaum, E. E. / Antiretroviral therapy adherence and viral suppression in HIV-infected drug users : Comparison of self-report and electronic monitoring. In: Clinical Infectious Diseases. 2001 ; Vol. 33, No. 8. pp. 1417-1423.
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