Antimicrobial dendrimer active against Escherichia coli biofilms

Shuyu Hou, Chunhui Zhou, Zhigang Liu, Anne W. Young, Zhengshuang Shi, Dacheng Ren, Neville R. Kallenbach

Research output: Contribution to journalArticle

Abstract

We have investigated the ability of a previously reported antimicrobial peptide dendrimer (RW)4D to inactivate Escherichia coli RP437 in planktonic culture and in biofilms. The results show that the dendrimer inhibits bacterial growth in both planktonic and biofilm states. Live/Dead staining assays reveal that most bacteria in a preformed biofilm lose viability after treatment with this peptide. This result is in marked contrast to most existing reports that antimicrobial peptides are ineffective against mature bacterial biofilms.

Original languageEnglish (US)
Pages (from-to)5478-5481
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number18
DOIs
StatePublished - Sep 15 2009

Fingerprint

Dendrimers
Biofilms
Escherichia coli
Peptides
Assays
Bacteria
Staining and Labeling
Growth
Therapeutics

Keywords

  • Antimicrobial
  • Biofilm
  • Dendrimer peptide

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Hou, S., Zhou, C., Liu, Z., Young, A. W., Shi, Z., Ren, D., & Kallenbach, N. R. (2009). Antimicrobial dendrimer active against Escherichia coli biofilms. Bioorganic and Medicinal Chemistry Letters, 19(18), 5478-5481. https://doi.org/10.1016/j.bmcl.2009.07.077

Antimicrobial dendrimer active against Escherichia coli biofilms. / Hou, Shuyu; Zhou, Chunhui; Liu, Zhigang; Young, Anne W.; Shi, Zhengshuang; Ren, Dacheng; Kallenbach, Neville R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 18, 15.09.2009, p. 5478-5481.

Research output: Contribution to journalArticle

Hou, S, Zhou, C, Liu, Z, Young, AW, Shi, Z, Ren, D & Kallenbach, NR 2009, 'Antimicrobial dendrimer active against Escherichia coli biofilms', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 18, pp. 5478-5481. https://doi.org/10.1016/j.bmcl.2009.07.077
Hou, Shuyu ; Zhou, Chunhui ; Liu, Zhigang ; Young, Anne W. ; Shi, Zhengshuang ; Ren, Dacheng ; Kallenbach, Neville R. / Antimicrobial dendrimer active against Escherichia coli biofilms. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 18. pp. 5478-5481.
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