Antibiotics, birth mode, and diet shape microbiome maturation during early life

Nicholas A. Bokulich, Jennifer Chung, Thomas Battaglia, Nora Henderson, Melanie Jay, Huilin Li, Arnon D. Lieber, Fen Wu, Guillermo I. Perez-Perez, Yu Chen, William Schweizer, Xuhui Zheng, Monica Contreras, Maria Gloria Dominguez-Bello, Martin J. Blaser

Research output: Contribution to journalArticle

Abstract

Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.

Original languageEnglish (US)
Article number343ra82
JournalScience Translational Medicine
Volume8
Issue number343
DOIs
StatePublished - Jun 15 2016

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Microbiota
Parturition
Anti-Bacterial Agents
Diet
Cesarean Section
Mothers
Bacteria
Health

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bokulich, N. A., Chung, J., Battaglia, T., Henderson, N., Jay, M., Li, H., ... Blaser, M. J. (2016). Antibiotics, birth mode, and diet shape microbiome maturation during early life. Science Translational Medicine, 8(343), [343ra82]. https://doi.org/10.1126/scitranslmed.aad7121

Antibiotics, birth mode, and diet shape microbiome maturation during early life. / Bokulich, Nicholas A.; Chung, Jennifer; Battaglia, Thomas; Henderson, Nora; Jay, Melanie; Li, Huilin; Lieber, Arnon D.; Wu, Fen; Perez-Perez, Guillermo I.; Chen, Yu; Schweizer, William; Zheng, Xuhui; Contreras, Monica; Dominguez-Bello, Maria Gloria; Blaser, Martin J.

In: Science Translational Medicine, Vol. 8, No. 343, 343ra82, 15.06.2016.

Research output: Contribution to journalArticle

Bokulich, NA, Chung, J, Battaglia, T, Henderson, N, Jay, M, Li, H, Lieber, AD, Wu, F, Perez-Perez, GI, Chen, Y, Schweizer, W, Zheng, X, Contreras, M, Dominguez-Bello, MG & Blaser, MJ 2016, 'Antibiotics, birth mode, and diet shape microbiome maturation during early life', Science Translational Medicine, vol. 8, no. 343, 343ra82. https://doi.org/10.1126/scitranslmed.aad7121
Bokulich, Nicholas A. ; Chung, Jennifer ; Battaglia, Thomas ; Henderson, Nora ; Jay, Melanie ; Li, Huilin ; Lieber, Arnon D. ; Wu, Fen ; Perez-Perez, Guillermo I. ; Chen, Yu ; Schweizer, William ; Zheng, Xuhui ; Contreras, Monica ; Dominguez-Bello, Maria Gloria ; Blaser, Martin J. / Antibiotics, birth mode, and diet shape microbiome maturation during early life. In: Science Translational Medicine. 2016 ; Vol. 8, No. 343.
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