Abstract
Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
| Original language | English (US) |
|---|---|
| Article number | 343ra82 |
| Journal | Science Translational Medicine |
| Volume | 8 |
| Issue number | 343 |
| DOIs | |
| State | Published - Jun 15 2016 |
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ASJC Scopus subject areas
- Medicine(all)
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Antibiotics, birth mode, and diet shape microbiome maturation during early life. / Bokulich, Nicholas A.; Chung, Jennifer; Battaglia, Thomas; Henderson, Nora; Jay, Melanie; Li, Huilin; Lieber, Arnon D.; Wu, Fen; Perez-Perez, Guillermo I.; Chen, Yu; Schweizer, William; Zheng, Xuhui; Contreras, Monica; Dominguez-Bello, Maria Gloria; Blaser, Martin J.
In: Science Translational Medicine, Vol. 8, No. 343, 343ra82, 15.06.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antibiotics, birth mode, and diet shape microbiome maturation during early life
AU - Bokulich, Nicholas A.
AU - Chung, Jennifer
AU - Battaglia, Thomas
AU - Henderson, Nora
AU - Jay, Melanie
AU - Li, Huilin
AU - Lieber, Arnon D.
AU - Wu, Fen
AU - Perez-Perez, Guillermo I.
AU - Chen, Yu
AU - Schweizer, William
AU - Zheng, Xuhui
AU - Contreras, Monica
AU - Dominguez-Bello, Maria Gloria
AU - Blaser, Martin J.
PY - 2016/6/15
Y1 - 2016/6/15
N2 - Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
AB - Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.
UR - http://www.scopus.com/inward/record.url?scp=84975068696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975068696&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.aad7121
DO - 10.1126/scitranslmed.aad7121
M3 - Article
C2 - 27306664
AN - SCOPUS:84975068696
VL - 8
JO - Science Translational Medicine
JF - Science Translational Medicine
SN - 1946-6234
IS - 343
M1 - 343ra82
ER -