Anthropometry and head and neck cancer: A pooled analysis of cohort data

Mia M. Gaudet, Cari M. Kitahara, Christina C. Newton, Leslie Bernstein, Peggy Reynolds, Elisabete Weiderpass, Aimée R. Kreimer, Gong Yang, Hans Olov Adami, Michael C. Alavanja, Laura E. Beane Freeman, Heiner Boeing, Julie Buring, Anil Chaturvedi, Yu Chen, Aimee A. D'Aloisio, Michal Freedman, Yu Tang Gao, J. Michael Gaziano, Graham G. GilesNiclas Håkansson, Wen Yi Huang, I. Min Lee, Martha S. Linet, Robert J. MacInnis, Yikyung Park, Anna Prizment, Mark P. Purdue, Elio Riboli, Kim Robien, Dale P. Sandler, Catherine Schairer, Howard D. Sesso, Xiao Ou Shu, Emily White, Alicja Wolk, Yong Bing Xiang, Anne Zelenuich-Jacquotte, Wei Zheng, Alpa V. Patel, Patricia Hartge, Amy Berrington De González, Susan M. Gapstur

Research output: Contribution to journalArticle

Abstract

Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

Original languageEnglish (US)
Article numberdyv059
Pages (from-to)673-681
Number of pages9
JournalInternational Journal of Epidemiology
Volume44
Issue number2
DOIs
StatePublished - May 27 2015

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Anthropometry
Head and Neck Neoplasms
Cohort Studies
Confidence Intervals
Body Mass Index
Smoking
Waist-Hip Ratio
Waist Circumference
Proportional Hazards Models
Hip

Keywords

  • Head and neck neoplasms
  • Obesity
  • Smoking
  • Waist circumference
  • Waist-hip ratio

ASJC Scopus subject areas

  • Epidemiology
  • Medicine(all)

Cite this

Gaudet, M. M., Kitahara, C. M., Newton, C. C., Bernstein, L., Reynolds, P., Weiderpass, E., ... Gapstur, S. M. (2015). Anthropometry and head and neck cancer: A pooled analysis of cohort data. International Journal of Epidemiology, 44(2), 673-681. [dyv059]. https://doi.org/10.1093/ije/dyv059

Anthropometry and head and neck cancer : A pooled analysis of cohort data. / Gaudet, Mia M.; Kitahara, Cari M.; Newton, Christina C.; Bernstein, Leslie; Reynolds, Peggy; Weiderpass, Elisabete; Kreimer, Aimée R.; Yang, Gong; Adami, Hans Olov; Alavanja, Michael C.; Beane Freeman, Laura E.; Boeing, Heiner; Buring, Julie; Chaturvedi, Anil; Chen, Yu; D'Aloisio, Aimee A.; Freedman, Michal; Gao, Yu Tang; Gaziano, J. Michael; Giles, Graham G.; Håkansson, Niclas; Huang, Wen Yi; Lee, I. Min; Linet, Martha S.; MacInnis, Robert J.; Park, Yikyung; Prizment, Anna; Purdue, Mark P.; Riboli, Elio; Robien, Kim; Sandler, Dale P.; Schairer, Catherine; Sesso, Howard D.; Shu, Xiao Ou; White, Emily; Wolk, Alicja; Xiang, Yong Bing; Zelenuich-Jacquotte, Anne; Zheng, Wei; Patel, Alpa V.; Hartge, Patricia; De González, Amy Berrington; Gapstur, Susan M.

In: International Journal of Epidemiology, Vol. 44, No. 2, dyv059, 27.05.2015, p. 673-681.

Research output: Contribution to journalArticle

Gaudet, MM, Kitahara, CM, Newton, CC, Bernstein, L, Reynolds, P, Weiderpass, E, Kreimer, AR, Yang, G, Adami, HO, Alavanja, MC, Beane Freeman, LE, Boeing, H, Buring, J, Chaturvedi, A, Chen, Y, D'Aloisio, AA, Freedman, M, Gao, YT, Gaziano, JM, Giles, GG, Håkansson, N, Huang, WY, Lee, IM, Linet, MS, MacInnis, RJ, Park, Y, Prizment, A, Purdue, MP, Riboli, E, Robien, K, Sandler, DP, Schairer, C, Sesso, HD, Shu, XO, White, E, Wolk, A, Xiang, YB, Zelenuich-Jacquotte, A, Zheng, W, Patel, AV, Hartge, P, De González, AB & Gapstur, SM 2015, 'Anthropometry and head and neck cancer: A pooled analysis of cohort data', International Journal of Epidemiology, vol. 44, no. 2, dyv059, pp. 673-681. https://doi.org/10.1093/ije/dyv059
Gaudet MM, Kitahara CM, Newton CC, Bernstein L, Reynolds P, Weiderpass E et al. Anthropometry and head and neck cancer: A pooled analysis of cohort data. International Journal of Epidemiology. 2015 May 27;44(2):673-681. dyv059. https://doi.org/10.1093/ije/dyv059
Gaudet, Mia M. ; Kitahara, Cari M. ; Newton, Christina C. ; Bernstein, Leslie ; Reynolds, Peggy ; Weiderpass, Elisabete ; Kreimer, Aimée R. ; Yang, Gong ; Adami, Hans Olov ; Alavanja, Michael C. ; Beane Freeman, Laura E. ; Boeing, Heiner ; Buring, Julie ; Chaturvedi, Anil ; Chen, Yu ; D'Aloisio, Aimee A. ; Freedman, Michal ; Gao, Yu Tang ; Gaziano, J. Michael ; Giles, Graham G. ; Håkansson, Niclas ; Huang, Wen Yi ; Lee, I. Min ; Linet, Martha S. ; MacInnis, Robert J. ; Park, Yikyung ; Prizment, Anna ; Purdue, Mark P. ; Riboli, Elio ; Robien, Kim ; Sandler, Dale P. ; Schairer, Catherine ; Sesso, Howard D. ; Shu, Xiao Ou ; White, Emily ; Wolk, Alicja ; Xiang, Yong Bing ; Zelenuich-Jacquotte, Anne ; Zheng, Wei ; Patel, Alpa V. ; Hartge, Patricia ; De González, Amy Berrington ; Gapstur, Susan M. / Anthropometry and head and neck cancer : A pooled analysis of cohort data. In: International Journal of Epidemiology. 2015 ; Vol. 44, No. 2. pp. 673-681.
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abstract = "Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95{\%} confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95{\%} CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95{\%} CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95{\%} CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95{\%} CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95{\%} CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.",
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TY - JOUR

T1 - Anthropometry and head and neck cancer

T2 - A pooled analysis of cohort data

AU - Gaudet, Mia M.

AU - Kitahara, Cari M.

AU - Newton, Christina C.

AU - Bernstein, Leslie

AU - Reynolds, Peggy

AU - Weiderpass, Elisabete

AU - Kreimer, Aimée R.

AU - Yang, Gong

AU - Adami, Hans Olov

AU - Alavanja, Michael C.

AU - Beane Freeman, Laura E.

AU - Boeing, Heiner

AU - Buring, Julie

AU - Chaturvedi, Anil

AU - Chen, Yu

AU - D'Aloisio, Aimee A.

AU - Freedman, Michal

AU - Gao, Yu Tang

AU - Gaziano, J. Michael

AU - Giles, Graham G.

AU - Håkansson, Niclas

AU - Huang, Wen Yi

AU - Lee, I. Min

AU - Linet, Martha S.

AU - MacInnis, Robert J.

AU - Park, Yikyung

AU - Prizment, Anna

AU - Purdue, Mark P.

AU - Riboli, Elio

AU - Robien, Kim

AU - Sandler, Dale P.

AU - Schairer, Catherine

AU - Sesso, Howard D.

AU - Shu, Xiao Ou

AU - White, Emily

AU - Wolk, Alicja

AU - Xiang, Yong Bing

AU - Zelenuich-Jacquotte, Anne

AU - Zheng, Wei

AU - Patel, Alpa V.

AU - Hartge, Patricia

AU - De González, Amy Berrington

AU - Gapstur, Susan M.

PY - 2015/5/27

Y1 - 2015/5/27

N2 - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

AB - Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = < 0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = < 0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m2: HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m2: HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m2: HR = 0.76, 95% CI 0.71-0.82, P-value for trend = < 0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers. Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

KW - Head and neck neoplasms

KW - Obesity

KW - Smoking

KW - Waist circumference

KW - Waist-hip ratio

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