Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation

Stephanie C. Lazzaro, Mian Hou, Catarina Cunha, Joseph Ledoux, Christopher K. Cain

Research output: Contribution to journalArticle

Abstract

Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued fear conditioning. Systemic or intra-lateral amygdala terazosin delivered before conditioning enhanced short- and long-term memory. Terazosin delivered after conditioning did not affect consolidation. In vitro, terazosin impaired lateral amygdala inhibitory postsynaptic currents leading to facilitation of excitatory postsynaptic currents and long-term potentiation. Since alpha1 blockers are prescribed for hypertension and posttraumatic stress disorder, these results may have important clinical implications.

Original languageEnglish (US)
Pages (from-to)489-493
Number of pages5
JournalLearning and Memory
Volume17
Issue number10
DOIs
StatePublished - Oct 2010

Fingerprint

Terazosin
Long-Term Potentiation
Amygdala
Adrenergic Receptors
Fear
Inhibitory Postsynaptic Potentials
Adrenergic Antagonists
Long-Term Memory
Excitatory Postsynaptic Potentials
Post-Traumatic Stress Disorders
Emotions
Learning
Hypertension
Conditioning (Psychology)

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation. / Lazzaro, Stephanie C.; Hou, Mian; Cunha, Catarina; Ledoux, Joseph; Cain, Christopher K.

In: Learning and Memory, Vol. 17, No. 10, 10.2010, p. 489-493.

Research output: Contribution to journalArticle

Lazzaro, Stephanie C. ; Hou, Mian ; Cunha, Catarina ; Ledoux, Joseph ; Cain, Christopher K. / Antagonism of lateral amygdala alpha1-adrenergic receptors facilitates fear conditioning and long-term potentiation. In: Learning and Memory. 2010 ; Vol. 17, No. 10. pp. 489-493.
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