Anosmin-1 is essential for neural crest and cranial placodes formation in Xenopus

Chang Joon Bae, Chang Soo Hong, Jean-Pierre Saint-Jeannet

Research output: Contribution to journalArticle

Abstract

During embryogenesis vertebrates develop a complex craniofacial skeleton associated with sensory organs. These structures are primarily derived from two embryonic cell populations the neural crest and cranial placodes, respectively. Neural crest cells and cranial placodes are specified through the integrated action of several families of signaling molecules, and the subsequent activation of a complex network of transcription factors. Here we describe the expression and function of Anosmin-1 (Anos1), an extracellular matrix protein, during neural crest and cranial placodes development in Xenopus laevis. Anos1 was identified as a target of Pax3 and Zic1, two transcription factors necessary and sufficient to generate neural crest and cranial placodes. Anos1 is expressed in cranial neural crest progenitors at early neurula stage and in cranial placode derivatives later in development. We show that Anos1 function is required for neural crest and sensory organs development in Xenopus, consistent with the defects observed in Kallmann syndrome patients carrying a mutation in ANOS1. These findings indicate that anos1 has a conserved function in the development of craniofacial structures, and indicate that anos1-depleted Xenopus embryos represent a useful model to analyze the pathogenesis of Kallmann syndrome.

Original languageEnglish (US)
Pages (from-to)2257-2263
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume495
Issue number3
DOIs
StatePublished - Jan 15 2018

Fingerprint

Neural Crest
Xenopus
Transcription Factors
Kallmann Syndrome
Extracellular Matrix Proteins
Complex networks
Chemical activation
Cells
Derivatives
Defects
Molecules
Xenopus laevis
Skeleton
Embryonic Development
Vertebrates
Embryonic Structures
Mutation
Population

Keywords

  • Anosmin-1
  • Cranial placode
  • Kallmann syndrome
  • Neural crest
  • Sensory organs
  • Xenopus

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Anosmin-1 is essential for neural crest and cranial placodes formation in Xenopus. / Bae, Chang Joon; Hong, Chang Soo; Saint-Jeannet, Jean-Pierre.

In: Biochemical and Biophysical Research Communications, Vol. 495, No. 3, 15.01.2018, p. 2257-2263.

Research output: Contribution to journalArticle

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