Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals

P. M. Frossard, A. M. Bokhari, Y. I. Elshahat, G. G. Lestringant, A. M. John, S. H. Hill, Abdishakur Abdulle, E. N. Obineche

    Research output: Contribution to journalArticle

    Abstract

    Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention, ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28% of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.

    Original languageEnglish (US)
    Pages (from-to)713-719
    Number of pages7
    JournalSaudi Medical Journal
    Volume19
    Issue number6
    StatePublished - Dec 1 1998

    Fingerprint

    United Arab Emirates
    Peptidyl-Dipeptidase A
    Cardiovascular Diseases
    Left Ventricular Hypertrophy
    Myocardial Ischemia
    Alleles
    Hypertension
    Myocardial Infarction
    Base Pairing
    Population
    Case-Control Studies

    Keywords

    • Angiotensin-converting enzyme
    • Cardiovascular diseases
    • Genetics
    • Hypertension
    • Myocardial infarction
    • Polymerase chain reaction

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Frossard, P. M., Bokhari, A. M., Elshahat, Y. I., Lestringant, G. G., John, A. M., Hill, S. H., ... Obineche, E. N. (1998). Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals. Saudi Medical Journal, 19(6), 713-719.

    Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals. / Frossard, P. M.; Bokhari, A. M.; Elshahat, Y. I.; Lestringant, G. G.; John, A. M.; Hill, S. H.; Abdulle, Abdishakur; Obineche, E. N.

    In: Saudi Medical Journal, Vol. 19, No. 6, 01.12.1998, p. 713-719.

    Research output: Contribution to journalArticle

    Frossard, PM, Bokhari, AM, Elshahat, YI, Lestringant, GG, John, AM, Hill, SH, Abdulle, A & Obineche, EN 1998, 'Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals', Saudi Medical Journal, vol. 19, no. 6, pp. 713-719.
    Frossard, P. M. ; Bokhari, A. M. ; Elshahat, Y. I. ; Lestringant, G. G. ; John, A. M. ; Hill, S. H. ; Abdulle, Abdishakur ; Obineche, E. N. / Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals. In: Saudi Medical Journal. 1998 ; Vol. 19, No. 6. pp. 713-719.
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    abstract = "Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention, ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28{\%} of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.",
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    T1 - Angiotensin-converting enzyme insertion or deletion dimorphism in predisposition to cardiovascular diseases amongst United Arab Emirates nationals

    AU - Frossard, P. M.

    AU - Bokhari, A. M.

    AU - Elshahat, Y. I.

    AU - Lestringant, G. G.

    AU - John, A. M.

    AU - Hill, S. H.

    AU - Abdulle, Abdishakur

    AU - Obineche, E. N.

    PY - 1998/12/1

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    N2 - Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention, ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28% of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.

    AB - Objectives: The absence of a 287 base pairs Alu sequence in the angiotensin-converting enzyme gene (D allele) is associated with higher angiotensin converting enzyme levels than its presence (I allele). There is, however, a huge body of conflicting reports that have linked angiotensin-converting enzyme insertion/deletion to hypertension, ischaemic heart disease, myocardial infarction, left ventricular hypertrophy, as well as several other clinical entities. We carried out a retrospective, case-control study of the angiotensin-converting enzyme insertion/deletion dimorphism in relation to circulating angiotensin-converting enzyme activity, as well as to hypertention, ischemic heart disease, myocardial infaction and left ventricular hypertrophy, amongst United Arab Emirates nationals subjects (Emirati). Methods: We investigated a sample population of 285 Emirati comprising groups of controls and of patients with clinical diagnoses of hypertension, ischaemic heart disease, myocardial infaction and left ventricular hypertrophy. Angiotensin-converting enzyme insertion/deletion genotypes were determined by assays based on polymerase chain reaction. Results: The D allele was associated with increased circulating angiotensin-converting enzyme activity, and the angiotensin-converting enzyme insertion/deletion marker accounted for 28% of the variance of the phenomenon determining angiotensin-converting enzyme levels. We found, however, no association between angiotensin-converting enzyme insertion/deletion and clinical diagnoses of hypertension, ischaemic heart disease, myocardial infarction and left ventricular hypertrophy. Conclusion: Although the D allele of the angiotensin converting enzyme insertion/deletion dimorphism tracks with circulating angiotensin-converting enzyme activities in United Arab Emirates nationals, it does not constitute a predictive marker for CVDs in this population.

    KW - Angiotensin-converting enzyme

    KW - Cardiovascular diseases

    KW - Genetics

    KW - Hypertension

    KW - Myocardial infarction

    KW - Polymerase chain reaction

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