Ancient and recent positive selection transformed opioid cis-regulation in humans.

Matthew V. Rockman, Matthew W. Hahn, Nicole Soranzo, Fritz Zimprich, David B. Goldstein, Gregory A. Wray

Research output: Contribution to journalArticle

Abstract

Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory. Independent lines of phylogenetic and population genetic evidence support a history of selective sweeps driving the evolution of the human prodynorphin promoter. In experimental assays of chimpanzee-human hybrid promoters, the selected sequence increases transcriptional inducibility. The evidence for a change in the response of the brain's natural opioids to inductive stimuli points to potential human-specific characteristics favored during evolution. In addition, the pattern of linked nucleotide and microsatellite variation among and within modern human populations suggests that recent selection, subsequent to the fixation of the human-specific mutations and the peopling of the globe, has favored different prodynorphin cis-regulatory alleles in different parts of the world.

Original languageEnglish (US)
Article numbere387
Pages (from-to)1-12
Number of pages12
JournalPLoS Biology
Volume3
Issue number12
DOIs
StatePublished - Dec 2005

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narcotics
Opioid Analgesics
Genetic Selection
natural selection
Neuropeptides
Microsatellite Repeats
promoter regions
Assays
Brain
Nucleotides
Genes
neuropeptides
Data storage equipment
Molecules
Pan troglodytes
human population
Population Genetics
population genetics
nucleotides
preproenkephalin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Rockman, M. V., Hahn, M. W., Soranzo, N., Zimprich, F., Goldstein, D. B., & Wray, G. A. (2005). Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biology, 3(12), 1-12. [e387]. https://doi.org/10.1371/journal.pbio.0030387

Ancient and recent positive selection transformed opioid cis-regulation in humans. / Rockman, Matthew V.; Hahn, Matthew W.; Soranzo, Nicole; Zimprich, Fritz; Goldstein, David B.; Wray, Gregory A.

In: PLoS Biology, Vol. 3, No. 12, e387, 12.2005, p. 1-12.

Research output: Contribution to journalArticle

Rockman, MV, Hahn, MW, Soranzo, N, Zimprich, F, Goldstein, DB & Wray, GA 2005, 'Ancient and recent positive selection transformed opioid cis-regulation in humans.', PLoS Biology, vol. 3, no. 12, e387, pp. 1-12. https://doi.org/10.1371/journal.pbio.0030387
Rockman, Matthew V. ; Hahn, Matthew W. ; Soranzo, Nicole ; Zimprich, Fritz ; Goldstein, David B. ; Wray, Gregory A. / Ancient and recent positive selection transformed opioid cis-regulation in humans. In: PLoS Biology. 2005 ; Vol. 3, No. 12. pp. 1-12.
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