Analytical Approach to the Protein Design Problem

Edo Kussell, Eugene I. Shakhnovich

Research output: Contribution to journalArticle

Abstract

We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a hierarchy of structures, from most to least designable, and show that this hierarchy depends on the potential that is used.

Original languageEnglish (US)
Pages (from-to)4437-4440
Number of pages4
JournalPhysical Review Letters
Volume83
Issue number21
StatePublished - Nov 22 1999

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Analytical Approach to the Protein Design Problem. / Kussell, Edo; Shakhnovich, Eugene I.

In: Physical Review Letters, Vol. 83, No. 21, 22.11.1999, p. 4437-4440.

Research output: Contribution to journalArticle

Kussell, E & Shakhnovich, EI 1999, 'Analytical Approach to the Protein Design Problem', Physical Review Letters, vol. 83, no. 21, pp. 4437-4440.
Kussell, Edo ; Shakhnovich, Eugene I. / Analytical Approach to the Protein Design Problem. In: Physical Review Letters. 1999 ; Vol. 83, No. 21. pp. 4437-4440.
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