Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change

Mathilde Ravier, Sungmin Hong, Charly Girot, Hiroshi Ishikawa, Jenna Tauber, Gadi Wollstein, Joel Schuman, James Fishbaugh, Guido Gerig

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Glaucoma is the second leading cause of blindness worldwide. Despite active research efforts driven by the importance of diagnosis and treatment of the optic degenerative neuropathy, the relationship between structural and functional changes along the glaucomateous evolution are still not clearly understood. Dynamic changes of the lamina cribrosa (LC) in the presence of intraocular pressure (IOP) were suggested to play a significant role in optic nerve damage, which motivates the proposed research to explore the relationship of changes of the 3D structure of the LC collagen meshwork to clinical diagnosis. We introduce a framework to quantify 3D dynamic morphological changes of the LC under acute IOP changes in a series of swept-source optical coherence tomography (SS-OCT) scans taken under different pressure states. Analysis of SS-OCT images faces challenges due to low signal-to-noise ratio, anisotropic resolution, and observation variability caused by subject and ocular motions. We adapt unbiased diffeomorphic atlas building which serves multiple purposes critical for this analysis. Analysis of deformation fields yields desired global and local information on pressure-induced geometric changes. Deformation variability, estimated with repeated images of a healthy volunteer without IOP elevation, is found to be a magnitude smaller than pressure-induced changes and thus illustrates feasibility of the proposed framework. Results in a clinical study with healthy, glaucoma suspect, and glaucoma subjects demonstrate the potential of the proposed method for non-invasive in vivo analysis of LC dynamics, potentially leading to early prediction and diagnosis of glaucoma.

    Original languageEnglish (US)
    Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
    EditorsGabor Fichtinger, Christos Davatzikos, Carlos Alberola-López, Alejandro F. Frangi, Julia A. Schnabel
    PublisherSpringer-Verlag
    Pages364-371
    Number of pages8
    ISBN (Print)9783030009335
    DOIs
    StatePublished - Jan 1 2018
    Event21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain
    Duration: Sep 16 2018Sep 20 2018

    Publication series

    NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
    Volume11071 LNCS
    ISSN (Print)0302-9743
    ISSN (Electronic)1611-3349

    Other

    Other21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018
    CountrySpain
    CityGranada
    Period9/16/189/20/18

    Fingerprint

    Lamina
    Acute
    Optical Coherence Tomography
    Optical tomography
    Sweep
    Optics
    Collagen
    Atlas
    Nerve
    Signal to noise ratio
    Quantify
    Damage
    Face
    Series
    Motion
    Prediction
    Demonstrate

    ASJC Scopus subject areas

    • Theoretical Computer Science
    • Computer Science(all)

    Cite this

    Ravier, M., Hong, S., Girot, C., Ishikawa, H., Tauber, J., Wollstein, G., ... Gerig, G. (2018). Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change. In G. Fichtinger, C. Davatzikos, C. Alberola-López, A. F. Frangi, & J. A. Schnabel (Eds.), Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings (pp. 364-371). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11071 LNCS). Springer-Verlag. https://doi.org/10.1007/978-3-030-00934-2_41

    Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change. / Ravier, Mathilde; Hong, Sungmin; Girot, Charly; Ishikawa, Hiroshi; Tauber, Jenna; Wollstein, Gadi; Schuman, Joel; Fishbaugh, James; Gerig, Guido.

    Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. ed. / Gabor Fichtinger; Christos Davatzikos; Carlos Alberola-López; Alejandro F. Frangi; Julia A. Schnabel. Springer-Verlag, 2018. p. 364-371 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11071 LNCS).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Ravier, M, Hong, S, Girot, C, Ishikawa, H, Tauber, J, Wollstein, G, Schuman, J, Fishbaugh, J & Gerig, G 2018, Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change. in G Fichtinger, C Davatzikos, C Alberola-López, AF Frangi & JA Schnabel (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11071 LNCS, Springer-Verlag, pp. 364-371, 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018, Granada, Spain, 9/16/18. https://doi.org/10.1007/978-3-030-00934-2_41
    Ravier M, Hong S, Girot C, Ishikawa H, Tauber J, Wollstein G et al. Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change. In Fichtinger G, Davatzikos C, Alberola-López C, Frangi AF, Schnabel JA, editors, Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. Springer-Verlag. 2018. p. 364-371. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-030-00934-2_41
    Ravier, Mathilde ; Hong, Sungmin ; Girot, Charly ; Ishikawa, Hiroshi ; Tauber, Jenna ; Wollstein, Gadi ; Schuman, Joel ; Fishbaugh, James ; Gerig, Guido. / Analysis of morphological changes of lamina cribrosa under acute intraocular pressure change. Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. editor / Gabor Fichtinger ; Christos Davatzikos ; Carlos Alberola-López ; Alejandro F. Frangi ; Julia A. Schnabel. Springer-Verlag, 2018. pp. 364-371 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).
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