An overview of scaffold design and fabrication technology for engineered knee meniscus

Jie Sun, Sanjairaj Vijayavenkataraman, Hang Liu

Research output: Contribution to journalReview article

Abstract

Current surgical treatments for meniscal tears suffer from subsequent degeneration of knee joints, limited donor organs and inconsistent post-treatment results. Three clinical scaffolds (Menaflex CMI, Actifit® scaffold and NUsurface® Meniscus Implant) are available on the market, but additional data are needed to properly evaluate their safety and effectiveness. Thus, many scaffold-based research activities have been done to develop new materials, structures and fabrication technologies to mimic native meniscus for cell attachment and subsequent tissue development, and restore functionalities of injured meniscus for long-term effects. This study begins with a synopsis of relevant structural features of meniscus and goes on to describe the critical considerations. Promising advances made in the field of meniscal scaffolding technology, in terms of biocompatible materials, fabrication methods, structure design and their impact on mechanical and biological properties are discussed in detail. Among all the scaffolding technologies, additive manufacturing (AM) is very promising because of its ability to precisely control fiber diameter, orientation, and pore network micro-architecture to mimic the native meniscus microenvironment.

Original languageEnglish (US)
Article number29
JournalMaterials
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2017

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Scaffolds
Fabrication
3D printers
Biocompatible Materials
Fiber reinforced materials
Biomaterials
Tissue

Keywords

  • Additive manufacturing
  • Meniscal scaffold
  • Scaffold design and fabrication

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

An overview of scaffold design and fabrication technology for engineered knee meniscus. / Sun, Jie; Vijayavenkataraman, Sanjairaj; Liu, Hang.

In: Materials, Vol. 10, No. 1, 29, 01.01.2017.

Research output: Contribution to journalReview article

Sun, Jie ; Vijayavenkataraman, Sanjairaj ; Liu, Hang. / An overview of scaffold design and fabrication technology for engineered knee meniscus. In: Materials. 2017 ; Vol. 10, No. 1.
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