An orthosteric inhibitor of the Ras-Sos interaction

Anupam Patgiri, Kamlesh K. Yadav, Paramjit S. Arora, Dafna Bar-Sagi

Research output: Contribution to journalArticle

Abstract

Mimics of α-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-permeable synthetic α-helix, based on the guanine nucleotide exchange factor Sos, that interferes with Ras-Sos interaction and downregulates Ras signaling in response to receptor tyrosine kinase activation.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalNature Chemical Biology
Volume7
Issue number9
DOIs
StatePublished - Sep 2011

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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