An orthosteric inhibitor of the Ras-Sos interaction

Anupam Patgiri, Kamlesh K. Yadav, Paramjit Arora, Dafna Bar-Sagi

Research output: Contribution to journalArticle

Abstract

Mimics of α-helices on protein surfaces have emerged as powerful reagents for antagonizing protein-protein interactions, which are difficult to target with small molecules. Here we describe the design of a cell-permeable synthetic α-helix, based on the guanine nucleotide exchange factor Sos, that interferes with Ras-Sos interaction and downregulates Ras signaling in response to receptor tyrosine kinase activation.

Original languageEnglish (US)
Pages (from-to)585-587
Number of pages3
JournalNature Chemical Biology
Volume7
Issue number9
DOIs
StatePublished - Sep 2011

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Artificial Cells
Guanine Nucleotide Exchange Factors
Receptor Protein-Tyrosine Kinases
Membrane Proteins
Proteins
Down-Regulation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

An orthosteric inhibitor of the Ras-Sos interaction. / Patgiri, Anupam; Yadav, Kamlesh K.; Arora, Paramjit; Bar-Sagi, Dafna.

In: Nature Chemical Biology, Vol. 7, No. 9, 09.2011, p. 585-587.

Research output: Contribution to journalArticle

Patgiri, Anupam ; Yadav, Kamlesh K. ; Arora, Paramjit ; Bar-Sagi, Dafna. / An orthosteric inhibitor of the Ras-Sos interaction. In: Nature Chemical Biology. 2011 ; Vol. 7, No. 9. pp. 585-587.
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