An optimal hydrogen-bond surrogate for α-helices

Stephen T. Joy, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Substitution of a main chain i → i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the α-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize α-helices in diverse peptide sequences.

Original languageEnglish (US)
Pages (from-to)5738-5741
Number of pages4
JournalChemical Communications
Volume52
Issue number33
DOIs
StatePublished - Apr 28 2016

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Peptides
Hydrogen bonds
Covalent bonds
Alkenes
Olefins
Conformations
Substitution reactions

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

An optimal hydrogen-bond surrogate for α-helices. / Joy, Stephen T.; Arora, Paramjit.

In: Chemical Communications, Vol. 52, No. 33, 28.04.2016, p. 5738-5741.

Research output: Contribution to journalArticle

Joy, Stephen T. ; Arora, Paramjit. / An optimal hydrogen-bond surrogate for α-helices. In: Chemical Communications. 2016 ; Vol. 52, No. 33. pp. 5738-5741.
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