An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory

Christopher P. Fall, John Rinzel

Research output: Contribution to journalArticle

Abstract

We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca2+ handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca2+ subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full "hybrid" network sustains IP3-dependent persistent ("bump") activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise - its position does not drift with time.

Original languageEnglish (US)
Pages (from-to)97-107
Number of pages11
JournalJournal of Computational Neuroscience
Volume20
Issue number1
DOIs
StatePublished - Feb 1 2006

Keywords

  • Calcium signaling
  • Computational model
  • Inositol 1,4,5 trisphosphate
  • Neuromodulators
  • Persistent activity
  • Working memory

ASJC Scopus subject areas

  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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