An elastic analysis of Listeria monocytogenes propulsion

Fabien Gerbal, Paul Chaikin, Yitzhak Rabin, Jacques Prost

    Research output: Contribution to journalArticle

    Abstract

    The bacterium Listeria monocytogenes uses the energy of the actin polymerization to propel itself through infected tissues. In steady state, it continuously adds new polymerized filaments to its surface, pushing on its tail, which is made from previously cross-linked actin filaments. In this paper we introduce an elastic model to describe how the addition of actin filaments to the tail results in the propulsive force on the bacterium. Filament growth on the bacterial surface produces stresses that are relieved at the back of the bacterium as it moves forward. The model leads to a natural competition between growth from the sides and growth from the back of the bacterium, with different velocities and strengths for each. This competition can lead to the periodic motion observed in a Listeria mutant.

    Original languageEnglish (US)
    Pages (from-to)2259-2275
    Number of pages17
    JournalBiophysical Journal
    Volume79
    Issue number5
    StatePublished - 2000

    Fingerprint

    Listeria monocytogenes
    Bacteria
    Actin Cytoskeleton
    Growth
    Listeria
    Polymerization
    Actins

    ASJC Scopus subject areas

    • Biophysics

    Cite this

    Gerbal, F., Chaikin, P., Rabin, Y., & Prost, J. (2000). An elastic analysis of Listeria monocytogenes propulsion. Biophysical Journal, 79(5), 2259-2275.

    An elastic analysis of Listeria monocytogenes propulsion. / Gerbal, Fabien; Chaikin, Paul; Rabin, Yitzhak; Prost, Jacques.

    In: Biophysical Journal, Vol. 79, No. 5, 2000, p. 2259-2275.

    Research output: Contribution to journalArticle

    Gerbal, F, Chaikin, P, Rabin, Y & Prost, J 2000, 'An elastic analysis of Listeria monocytogenes propulsion', Biophysical Journal, vol. 79, no. 5, pp. 2259-2275.
    Gerbal F, Chaikin P, Rabin Y, Prost J. An elastic analysis of Listeria monocytogenes propulsion. Biophysical Journal. 2000;79(5):2259-2275.
    Gerbal, Fabien ; Chaikin, Paul ; Rabin, Yitzhak ; Prost, Jacques. / An elastic analysis of Listeria monocytogenes propulsion. In: Biophysical Journal. 2000 ; Vol. 79, No. 5. pp. 2259-2275.
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