An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients

Clive R. Pullinger, Bradley E. Aouizerat, Irina Movsesyan, Vincent Durlach, Eric J. Sijbrands, Katsuyuki Nakajima, Annie Poon, Geesje M. Dallinga-Thie, Hiroaki Hattori, Lauri L. Green, Pui Yan Kwok, Richard J. Havel, Philip H. Frost, Mary J. Malloy, John P. Kane

Research output: Contribution to journalArticle

Abstract

Apolipoprotein A-V (apoA-V) is an important regulator of plasma levels of triglyceride (TG) in mice. In humans, APOA5 genetic variation is associated with TG in several populations. In this study, we determined the effects of the p.185Gly>Cys (c.553G>T; rs2075291) polymorphism on plasma TG levels in subjects of Chinese ancestry living in the United States and in a group of non-Chinese Asian ancestry. The frequency of the less common cysteine allele was 4-fold higher (15.1% vs. 3.7%) in Chinese high-TG subjects compared with a low-TG group (Chi-square 5 20.2; P>, 0.0001), corresponding with a 4.45 times higher risk of hypertriglyceridemia (95% confidence interval, 2.18-9.07; P>, 0.001). These results were replicated in the non-Chinese Asians. Heterozygosity was associated, in the high-TG group, with a doubling of TG (P

Original languageEnglish (US)
Pages (from-to)1846-1854
Number of pages9
JournalJournal of Lipid Research
Volume49
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Apolipoproteins A
Asian Americans
Hypertriglyceridemia
Single Nucleotide Polymorphism
Triglycerides
Genes
Plasmas
Medical Genetics
Apolipoprotein A-V
Polymorphism
Cysteine
Alleles
Confidence Intervals

Keywords

  • Chinese Americans
  • Haplotypes
  • Heart disease
  • High density lipoprotein
  • Lipoprotein lipase
  • Polymorphism
  • Single nucleotide polymorphism
  • Triglycerides

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Endocrinology

Cite this

An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. / Pullinger, Clive R.; Aouizerat, Bradley E.; Movsesyan, Irina; Durlach, Vincent; Sijbrands, Eric J.; Nakajima, Katsuyuki; Poon, Annie; Dallinga-Thie, Geesje M.; Hattori, Hiroaki; Green, Lauri L.; Kwok, Pui Yan; Havel, Richard J.; Frost, Philip H.; Malloy, Mary J.; Kane, John P.

In: Journal of Lipid Research, Vol. 49, No. 8, 08.2008, p. 1846-1854.

Research output: Contribution to journalArticle

Pullinger, CR, Aouizerat, BE, Movsesyan, I, Durlach, V, Sijbrands, EJ, Nakajima, K, Poon, A, Dallinga-Thie, GM, Hattori, H, Green, LL, Kwok, PY, Havel, RJ, Frost, PH, Malloy, MJ & Kane, JP 2008, 'An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients', Journal of Lipid Research, vol. 49, no. 8, pp. 1846-1854. https://doi.org/10.1194/jlr.P800011-JLR200
Pullinger, Clive R. ; Aouizerat, Bradley E. ; Movsesyan, Irina ; Durlach, Vincent ; Sijbrands, Eric J. ; Nakajima, Katsuyuki ; Poon, Annie ; Dallinga-Thie, Geesje M. ; Hattori, Hiroaki ; Green, Lauri L. ; Kwok, Pui Yan ; Havel, Richard J. ; Frost, Philip H. ; Malloy, Mary J. ; Kane, John P. / An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients. In: Journal of Lipid Research. 2008 ; Vol. 49, No. 8. pp. 1846-1854.
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AU - Sijbrands, Eric J.

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AU - Hattori, Hiroaki

AU - Green, Lauri L.

AU - Kwok, Pui Yan

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AU - Frost, Philip H.

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AU - Kane, John P.

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