An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert, Sam Thompson, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalChemical Communications
Volume53
Issue number2
DOIs
StatePublished - 2017

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Peptidomimetics
Hydrazones
Imines
Scaffolds

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation. / Busschaert, Nathalie; Thompson, Sam; Hamilton, Andrew.

In: Chemical Communications, Vol. 53, No. 2, 2017, p. 313-316.

Research output: Contribution to journalArticle

Busschaert, Nathalie ; Thompson, Sam ; Hamilton, Andrew. / An α-helical peptidomimetic scaffold for dynamic combinatorial library formation. In: Chemical Communications. 2017 ; Vol. 53, No. 2. pp. 313-316.
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