Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

Tao Ma; Eric Klann

doi:10.1111/j.1471-4159.2011.07506.x

Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease

Tao Ma, Eric Klann

Neural Science

Research output: Contribution to journal › Review article

Abstract

Mounting evidence suggests that amyloid beta-induced impairments in synaptic plasticity that is accompanied by cognitive decline and dementia represent key pathogenic steps of Alzheimer's disease. In this study, we review recent advances in the study of the molecular and cellular mechanisms underlying Alzheimer's disease-associated synaptic dysfunction and memory deficits, and how these mechanisms could provide novel avenues for therapeutic intervention to treat this devastating neurodegenerative disease.

Original language	English (US)
Pages (from-to)	140-148
Number of pages	9
Journal	Journal of Neurochemistry
Volume	120
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1111/j.1471-4159.2011.07506.x
State	Published - Jan 1 2012

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Keywords

NMDA receptors
amyloid β
glycogen synthase kinase-3
long-term potentiation
mammalian target of rapamycin
reactive oxygen species

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Cite this

Ma, T., & Klann, E. (2012). Amyloid β: linking synaptic plasticity failure to memory disruption in Alzheimer's disease. Journal of Neurochemistry, 120(SUPPL. 1), 140-148. https://doi.org/10.1111/j.1471-4159.2011.07506.x

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10.1111/j.1471-4159.2011.07506.x