Amygdala-hippocampal shape differences in schizophrenia

The application of 3D shape models to volumetric MR data

Martha E. Shenton, Guido Gerig, Robert W. McCarley, Gábor Székely, Ron Kikinis

    Research output: Contribution to journalArticle

    Abstract

    Evidence suggests that some structural brain abnormalities in schizophrenia are neurodevelopmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities in neurodevelopment. While many magnetic resonance (MR) imaging studies have investigated brain area and volume measures in schizophrenia, fewer have focused on shape deformations. In this MR study we used a 3D shape representation technique, based on spherical harmonic functions, to analyze left and right amygdala-hippocampus shapes in each of 15 patients with schizophrenia and 15 healthy controls matched for age, gender, handedness and parental socioeconomic status. Left/right asymmetry was also measured for both shape and volume differences. Additionally, shape and volume measurements were combined in a composite analysis. There were no differences between groups in overall volume or shape. Left/right amygdala-hippocampal asymmetry, however, was significantly larger in patients than controls for both relative volume and shape. The local brain regions responsible for the left/right asymmetry differences in patients with schizophrenia were in the tail of the hippocampus (including both the inferior aspect adjacent to parahippocampal gyrus and the superior aspect adjacent to the lateral geniculate nucleus and more anteriorly to the cerebral peduncles) and in portions of the amygdala body (including the anterior-superior aspect adjacent to the basal nucleus). Also, in patients, increased volumetric asymmetry tended to be correlated with increased left/right shape asymmetry. Furthermore, a combined analysis of volume and shape asymmetry resulted in improved differentiation between groups. Classification function analyses correctly classified 70% of cases using volume, 73.3% using shape, and 87% using combined volume and shape measures. These findings suggest that shape provides important new information toward characterizing the pathophysiology of schizophrenia, and that combining volume and shape measures provides improved group discrimination in studies investigating brain abnormalities in schizophrenia. An evaluation of shape deformations also suggests local abnormalities in the amygdala-hippocampal complex in schizophrenia.

    Original languageEnglish (US)
    Pages (from-to)15-35
    Number of pages21
    JournalPsychiatry Research - Neuroimaging
    Volume115
    Issue number1-2
    DOIs
    StatePublished - Aug 20 2002

    Fingerprint

    Amygdala
    Schizophrenia
    Magnetic Resonance Spectroscopy
    Brain
    Hippocampus
    Geniculate Bodies
    Parahippocampal Gyrus
    Functional Laterality
    Basal Ganglia
    Social Class
    Magnetic Resonance Imaging

    Keywords

    • Amygdala-hippocampal complex
    • Hippocampus
    • Magnetic resonance imaging (MRI)
    • Neurodevelopmental abnormalities
    • Schizophrenia
    • Shape analysis
    • Shape deformations
    • Shape descriptors
    • Three-dimensional (3D) shape techniques

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Radiology Nuclear Medicine and imaging
    • Biological Psychiatry
    • Psychology(all)

    Cite this

    Amygdala-hippocampal shape differences in schizophrenia : The application of 3D shape models to volumetric MR data. / Shenton, Martha E.; Gerig, Guido; McCarley, Robert W.; Székely, Gábor; Kikinis, Ron.

    In: Psychiatry Research - Neuroimaging, Vol. 115, No. 1-2, 20.08.2002, p. 15-35.

    Research output: Contribution to journalArticle

    Shenton, Martha E. ; Gerig, Guido ; McCarley, Robert W. ; Székely, Gábor ; Kikinis, Ron. / Amygdala-hippocampal shape differences in schizophrenia : The application of 3D shape models to volumetric MR data. In: Psychiatry Research - Neuroimaging. 2002 ; Vol. 115, No. 1-2. pp. 15-35.
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    abstract = "Evidence suggests that some structural brain abnormalities in schizophrenia are neurodevelopmental in origin. There is also growing evidence to suggest that shape deformations in brain structure may reflect abnormalities in neurodevelopment. While many magnetic resonance (MR) imaging studies have investigated brain area and volume measures in schizophrenia, fewer have focused on shape deformations. In this MR study we used a 3D shape representation technique, based on spherical harmonic functions, to analyze left and right amygdala-hippocampus shapes in each of 15 patients with schizophrenia and 15 healthy controls matched for age, gender, handedness and parental socioeconomic status. Left/right asymmetry was also measured for both shape and volume differences. Additionally, shape and volume measurements were combined in a composite analysis. There were no differences between groups in overall volume or shape. Left/right amygdala-hippocampal asymmetry, however, was significantly larger in patients than controls for both relative volume and shape. The local brain regions responsible for the left/right asymmetry differences in patients with schizophrenia were in the tail of the hippocampus (including both the inferior aspect adjacent to parahippocampal gyrus and the superior aspect adjacent to the lateral geniculate nucleus and more anteriorly to the cerebral peduncles) and in portions of the amygdala body (including the anterior-superior aspect adjacent to the basal nucleus). Also, in patients, increased volumetric asymmetry tended to be correlated with increased left/right shape asymmetry. Furthermore, a combined analysis of volume and shape asymmetry resulted in improved differentiation between groups. Classification function analyses correctly classified 70{\%} of cases using volume, 73.3{\%} using shape, and 87{\%} using combined volume and shape measures. These findings suggest that shape provides important new information toward characterizing the pathophysiology of schizophrenia, and that combining volume and shape measures provides improved group discrimination in studies investigating brain abnormalities in schizophrenia. An evaluation of shape deformations also suggests local abnormalities in the amygdala-hippocampal complex in schizophrenia.",
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