Ammonia as a potential mediator of adult human periodontal infection

Inhibition of neutrophil function

Richard Niederman, B. Brunkhorst, S. Smith, R. N. Weinreb, M. I. Ryder

Research output: Contribution to journal › Article

Abstract

Neutrophils (polymorphonuclear leucocytes) are the principal cell of the host defence system. Consequently, if periodontal pathogen-derived substances in the gingival crevice significantly inhibit their function, they could shift the bacterial-host balance in favour of the bacteria. The hypothesis that ammonia can inhibit neutrophil function was tested. Ammonia was specifically selected because periodontal pathogens produce substantial amounts of ammonia. The findings indicated that ammonia can inhibit neutrophil phagocytosis, degranulation and oxygen metabolism. Ammonia decreased the total number of phagocytosing polymorphonuclear neutrophils (66% of control) and also decreased degranulation (61% of control). Ammonia decreased oxygen metabolism of both resting and stimulated neutrophils (33 and 42% of control, respectively). These observations support the hypothesis that ammonia can inhibit the function of polymorphonuclear leucocytes. They suggest that the presence of ammonia in the gingival crevice may increase the risk of development of periodonal disease.

Original languageEnglish (US)
JournalArchives of Oral Biology
Volume35
Issue numberSUPPL.
DOIs
StatePublished - 1990

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Ammonia
Neutrophils
Infection
Phagocytosis
Oxygen
Bacteria

Keywords

  • ammonia
  • degranulation
  • neutrophils
  • oxygen metabolism
  • periodontal disease
  • phagocytosis
  • polymorphonuclear leucocytes

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Ammonia as a potential mediator of adult human periodontal infection : Inhibition of neutrophil function. / Niederman, Richard; Brunkhorst, B.; Smith, S.; Weinreb, R. N.; Ryder, M. I.

In: Archives of Oral Biology, Vol. 35, No. SUPPL., 1990.

Research output: Contribution to journal › Article

Niederman, R, Brunkhorst, B, Smith, S, Weinreb, RN & Ryder, MI 1990, 'Ammonia as a potential mediator of adult human periodontal infection: Inhibition of neutrophil function', Archives of Oral Biology, vol. 35, no. SUPPL.. https://doi.org/10.1016/0003-9969(90)90159-8
Niederman R, Brunkhorst B, Smith S, Weinreb RN, Ryder MI. Ammonia as a potential mediator of adult human periodontal infection: Inhibition of neutrophil function. Archives of Oral Biology. 1990;35(SUPPL.). https://doi.org/10.1016/0003-9969(90)90159-8
Niederman, Richard ; Brunkhorst, B. ; Smith, S. ; Weinreb, R. N. ; Ryder, M. I. / Ammonia as a potential mediator of adult human periodontal infection : Inhibition of neutrophil function. In: Archives of Oral Biology. 1990 ; Vol. 35, No. SUPPL.
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