Altered histopathology in protein-deprived mice during Sendai virus pneumonia: Evidence for delayed inflammatory response and recovery

Victor Peña-Cruz, Roderick T. Bronson, Carol S. Reiss, Kenneth McIntosh

Research output: Contribution to journalArticle

Abstract

The morphology of the lungs and airway during the course of respiratory infection caused by Sendai virus was examined in normal (20% protein diet) and malnourished (2% protein diet) BALB/c mice. Mortality in normal Sendai-infected mice was 0 compared with 71% in the infected malnourished group. Virus was isolated until day 6 in normally fed mice and until day 9 in the malnourished group. Pulmonary inflammation was largely mononuclear and began in the normally nourished animals on day 3, peaked at day 6, and reverted almost to normal by 30 days. In the malnourished group, inflammation was delayed by about 1 day and fell further behind during the first week. It peaked 10-13 days after infection and was still present with little resolution by day 30. These findings may have relevance to the high mortality of acute respiratory diseases in children of the developing world.

Original languageEnglish (US)
Pages (from-to)846-851
Number of pages6
JournalJournal of Infectious Diseases
Volume165
Issue number5
StatePublished - May 1992

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Sendai virus
Pneumonia
Proteins
Mortality
Acute Disease
Respiratory Tract Infections
Diet
Viruses
Inflammation
Lung
Infection

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Altered histopathology in protein-deprived mice during Sendai virus pneumonia : Evidence for delayed inflammatory response and recovery. / Peña-Cruz, Victor; Bronson, Roderick T.; Reiss, Carol S.; McIntosh, Kenneth.

In: Journal of Infectious Diseases, Vol. 165, No. 5, 05.1992, p. 846-851.

Research output: Contribution to journalArticle

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