Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder

Matthew J. Hoptman, Jan Volavka, Pál Czobor, Guido Gerig, Miranda Chakos, Joseph Blocher, Leslie L. Citrome, Brain Sheitman, Jean Pierre Lindenmayer, Jeffrey A. Lieberman, Robert M. Bilder

    Research output: Contribution to journalArticle

    Abstract

    Caudate dysfunction is implicated in schizophrenia. However, little is known about the relationship between aggression and caudate volumes. Forty-nine patients received magnetic resonance imaging scanning in a double-blind treatment study in which aggression was measured. Caudate volumes were computed using a semiautomated method. The authors measured aggression with the Overt Aggression Scale and the Positive and Negative Syndrome Scale. Larger caudate volumes were associated with greater levels of aggression. The relationship between aggression and caudate volumes may be related to the iatrogenic effects of long-term treatment with typical antipsychotic agents or to a direct effect of schizophrenic processes on the caudate.

    Original languageEnglish (US)
    Pages (from-to)509-515
    Number of pages7
    JournalJournal of Neuropsychiatry and Clinical Neurosciences
    Volume18
    Issue number4
    DOIs
    StatePublished - Sep 2006

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    Aggression
    Psychotic Disorders
    Schizophrenia
    Double-Blind Method
    Antipsychotic Agents
    Magnetic Resonance Imaging
    Therapeutics

    ASJC Scopus subject areas

    • Neuropsychology and Physiological Psychology
    • Neuroscience(all)

    Cite this

    Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder. / Hoptman, Matthew J.; Volavka, Jan; Czobor, Pál; Gerig, Guido; Chakos, Miranda; Blocher, Joseph; Citrome, Leslie L.; Sheitman, Brain; Lindenmayer, Jean Pierre; Lieberman, Jeffrey A.; Bilder, Robert M.

    In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 18, No. 4, 09.2006, p. 509-515.

    Research output: Contribution to journalArticle

    Hoptman, MJ, Volavka, J, Czobor, P, Gerig, G, Chakos, M, Blocher, J, Citrome, LL, Sheitman, B, Lindenmayer, JP, Lieberman, JA & Bilder, RM 2006, 'Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder', Journal of Neuropsychiatry and Clinical Neurosciences, vol. 18, no. 4, pp. 509-515. https://doi.org/10.1176/appi.neuropsych.18.4.509
    Hoptman, Matthew J. ; Volavka, Jan ; Czobor, Pál ; Gerig, Guido ; Chakos, Miranda ; Blocher, Joseph ; Citrome, Leslie L. ; Sheitman, Brain ; Lindenmayer, Jean Pierre ; Lieberman, Jeffrey A. ; Bilder, Robert M. / Aggression and quantitative MRI measures of caudate in patients with chronic schizophrenia or schizoaffective disorder. In: Journal of Neuropsychiatry and Clinical Neurosciences. 2006 ; Vol. 18, No. 4. pp. 509-515.
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    AU - Chakos, Miranda

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    AU - Citrome, Leslie L.

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